Interleukin-13 Receptor α1-Dependent Responses in the Intestine Are Critical to Parasite Clearance

Infection and Immunity
Rex SunTerez Shea-Donohue

Abstract

Nematode infection upregulates interleukin-4 (IL-4) and IL-13 and induces STAT6-dependent changes in gut function that promote worm clearance. IL-4 and IL-13 activate the type 2 IL-4 receptor (IL-4R), which contains the IL-13Rα1 and IL-4Rα chains. We used mice deficient in IL-13Rα1 (IL-13Rα1(-/-)) to examine the contribution of IL-13 acting at the type 2 IL-4R to immune and functional responses to primary (Hb1) and secondary (Hb2) infections with the gastrointestinal nematode parasite Heligmosomoides bakeri There were differences between strains in the IL-4 and IL-13 expression responses to Hb1 but not Hb2 infection. Following Hb2 infection, deficient mice had impaired worm expulsion and higher worm fecundity despite normal production of Th2-derived cytokines. The upregulation of IL-25 and IL-13Rα2 in Hb1- and Hb2-infected wild-type (WT) mice was absent in IL-13Rα1(-/-)mice. Goblet cell numbers and resistin-like molecule beta (RELM-β) expression were attenuated significantly in IL-13Rα1(-/-)mice following Hb2 infections. IL-13Rα1 contributes to the development of alternatively activated macrophages, but the type 1 IL-4R is also important. Hb1 infection had no effects on smooth muscle function or epithelial permeability in eithe...Continue Reading

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Citations

Feb 25, 2017·Parasite Immunology·T Shea-DonohueA Smith
Mar 7, 2017·Scientific Reports·Kenneth ShatzkesDaniel E Kadouri
Jun 16, 2017·Cell Host & Microbe·Pei-Yun TsaiJerrold R Turner
Oct 17, 2017·Archives of Pharmacal Research·Jisu KimHyeyoung Min
May 8, 2018·Scientific Reports·Kim S LeMessurierAmali E Samarasinghe

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