Interleukin-13 receptor alpha2 is a novel therapeutic target for human adrenocortical carcinoma.

Cancer
Meenu JainElectron Kebebew

Abstract

Adrenocortical carcinoma (ACC) is a relatively rare but aggressive malignancy with limited therapeutic options. Previous genome-wide expression studies have demonstrated the overexpression of interleukin-13 receptor alpha2 (IL13Rα2) in some human malignancies. The authors evaluated IL13Rα2 mRNA and protein expression in 21 normal samples, 78 benign samples, 10 primary malignant samples, and 25 metastatic/recurrent samples and performed functional analyses with IL13 ligand and IL13 Rα2 knockdown in vitro. The sensitivity of 2 ACC cell lines (NCI-H295R [high IL13Rα2 expression] and SW13 [low IL13Rα2 expression]) to a highly specific IL-13 conjugated with Pseudomonas exotoxin (IL-13-PE) also was evaluated in both in vitro and in vivo models. IL13Rα2 was overexpressed in malignant tumors compared with benign and normal samples (15-fold higher; P < .05). Immunohistochemistry also confirmed higher protein expression in malignant and benign tumors than in normal adrenocortical tissues (P < .05). The half-maximal inhibitory concentration for IL-13-PE was 1.3 ng/mL in the NCI-H295R cell line and 1000 ng/mL in the SW13 cell line. Mice that received intratumoral or intraperitoneal IL-13-PE injection had a significant reduction in tumor si...Continue Reading

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References

Mar 1, 1997·Matrix Biology : Journal of the International Society for Matrix Biology·P BassetM C Rio
Nov 18, 1998·Current Opinion in Cell Biology·M JohnsenK Danø
Dec 4, 1998·Biochemistry·A Keppler-HafkemeyerI Pastan
Feb 19, 2000·Cancer·B L WajchenbergM A Kirschner
Oct 18, 2000·Critical Reviews in Oncology/hematology·W Mueller-Klieser
May 9, 2001·Annales de chirurgie·P IcardY Chapuis
May 2, 2002·Cell·John J O'SheaRobert D Schreiber
Jan 28, 2003·The American Journal of Pathology·Thomas J GiordanoSamir M Hanash
Mar 5, 2003·Annual Review of Immunology·Thomas A Wynn
Jul 29, 2005·Nature·Andy J MinnJoan Massagué
Dec 20, 2005·Surgery·David Velázquez-FernándezMartin Bäckdahl
Mar 25, 2006·European Journal of Endocrinology·E P SlaterD K Bartsch
May 9, 2006·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·C P LombardiR Bellantone
May 9, 2006·World Journal of Surgery·Electron KebebewAlex McMillan
Oct 25, 2006·Annual Review of Medicine·Ira PastanRobert J Kreitman
Sep 17, 2008·Archives of Surgery·Gustavo G Fernandez-RanvierElectron Kebebew
Dec 10, 2008·International Journal of Cancer. Journal International Du Cancer·Mitomu KioiRaj K Puri
May 16, 2009·Expert Review of Molecular Diagnostics·Insoo SuhElectron Kebebew
Jan 14, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Takeshi ShimamuraRaj K Puri

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Citations

Sep 26, 2013·Advanced Drug Delivery Reviews·Yu ChengMaciej S Lesniak
Mar 10, 2017·Current Opinion in Endocrinology, Diabetes, and Obesity·Jeena Varghese, Mouhammed Amir Habra
Mar 28, 2013·Endocrine-related Cancer·Meenu JainElectron Kebebew
Apr 23, 2016·Oncotarget·Ricardo CostaFrancis J Giles
Oct 18, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tatiana Paula T FerreiraPatrícia Machado Rodrigues E Silva
Feb 25, 2019·Current Oncology Reports·Sina Jasim, Mouhammed Amir Habra
Jul 11, 2019·The Journal of Clinical Endocrinology and Metabolism·Siao Ting ChongJoanne Ngeow
Jan 28, 2021·Biomedicines·Izabela KarwackaKrzysztof Sworczak
Apr 4, 2021·International Journal of Molecular Sciences·Jingwei ShiMarko Kornmann
Jun 3, 2021·Cancers·Guillaume J PegnaJaydira Del Rivero

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