Interleukin-15, a leukocyte activator and growth factor, is produced by cortical tubular epithelial cells.

Journal of the American Society of Nephrology : JASN
M WeilerA Douvdevani

Abstract

Many renal diseases, including transplant rejection, are mediated by mononuclear cells. Interleukin-15 (IL-15) has been recently described as a cytokine with IL-2-like activity. IL-15 is an effective leukocyte growth factor, activator, and chemoattractant. In rejected human kidney allografts, elevated IL-15, but not IL-2, mRNA is expressed, suggesting a role for IL-15 in the rejection process. The aim of this study was to investigate whether human cortical tubular epithelial cells (HTC) are able to produce IL-15 and whether IL-15 expression is regulated by inflammatory mediators. HTC were isolated and characterized, and IL-15 expression was analyzed by reverse transcription-PCR, enzyme-linked immunosorbent assay, and bioactivity. It was found that HTC constitutively express IL-15. Upon stimulation of HTC with interferon-gamma (IFN gamma), the levels of both mRNA and protein increased up to twofold. In contrast, lipopolysaccharide, IL-1, IL-2, and tumor necrosis factor-alpha had no detectable effect. IFN gamma action on HTC was dose-dependent from concentrations of 5 U/ml, reaching a plateau at 50 U/ml. HTC supernatants induced proliferation of the T cell line CTLD, which could be partially blocked (50%) by specific IL-15 antibo...Continue Reading

Citations

Feb 24, 2001·Current Opinion in Nephrology and Hypertension·C van Kooten, M R Daha
Jan 3, 2001·Journal of the American Society of Nephrology : JASN·Michal WeilerAmos Douvdevani
Mar 29, 2001·Journal of the American Society of Nephrology : JASN·Anna BasokAmos Douvdevani
Jan 3, 2001·Blood·T A Fehniger, M A Caligiuri
Sep 19, 2002·Biochemical and Biophysical Research Communications·Manabu YanagitaShinya Murakami
Dec 21, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Helen Robertson, John A Kirby
Oct 7, 2004·International Archives of Allergy and Immunology·Ning GeSaburo Sone
Jan 27, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Noa Tejman-YardenAmos Douvdevani
Apr 14, 2009·Transplantation Reviews·Christopher Y C Nguan, Caigan Du
Jan 23, 2003·Annals of the New York Academy of Sciences·Nan-Ping WengPierre A Henkart
Dec 5, 2009·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Hadar EiniAmos Douvdevani
Feb 6, 2010·Transplantation·Silke HausteinStuart J Knechtle

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