PMID: 9423851Jan 10, 1998Paper

Interleukin-15 augments superoxide production and microbicidal activity of human monocytes against Candida albicans

Infection and Immunity
N VázquezC A Lyman

Abstract

Interleukin-15 (IL-15) is a newly described cytokine that shares biological activities with IL-2. We report here results demonstrating the ability of IL-15 to enhance superoxide production and antifungal activity of human monocytes. After 18 and 48 h of treatment with IL-15, human elutriated monocytes manifested enhanced superoxide production in response to either phorbol myristate acetate or opsonized Candida albicans blastoconidia. Similar results were obtained when monocytes were treated with IL-2, but to a lesser extent. Combination studies with IL-15 and IL-2 showed no additive or synergistic effects. Following incubation of monocytes with IL-15 for 18 h, there was no significant increase in mRNA transcripts for components of the NADPH oxidase complex, p40-phox, p47-phox, and gp91-phox, suggesting a posttranscriptional modulation of enhanced superoxide production. Antibodies against the gamma chain of the IL-2 receptor and, to a lesser extent, against the beta chain partially abrogated the IL-15-mediated enhanced superoxide production. Additionally, human monocytes showed enhanced killing activity against C. albicans after 18 h of incubation with IL-15 or IL-2, but this treatment did not enhance the ability of these cells ...Continue Reading

References

Sep 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E Roilides, P A Pizzo
Dec 1, 1991·The Journal of Pediatrics·P A PizzoT J Walsh
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·P E NewburgerS H Orkin
May 1, 1995·International Journal of Immunopharmacology·L A BoberS K Narula
Jan 1, 1995·Journal of Leukocyte Biology·I Espinoza-DelgadoL Varesio
Mar 1, 1995·The Journal of Experimental Medicine·P C Wilkinson, F Y Liew
Aug 1, 1993·American Journal of Hematology·R C PerkinsA Holian
Mar 15, 1996·The Journal of Clinical Investigation·L FlamandJ Menezes

❮ Previous
Next ❯

Citations

Sep 18, 2002·Antimicrobial Agents and Chemotherapy·Daisuke KobayashiNaoki Watanabe
Feb 8, 2014·Expert Review of Gastroenterology & Hepatology·Georgia Malamut, Christophe Cellier
Jan 27, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bieke BrouxNiels Hellings
Sep 26, 2019·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Bhavnita Soni, Shailza Singh
Jul 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·F MatteiD F Tough
May 27, 2005·British Journal of Haematology·Charalampos Antachopoulos, Emmanuel Roilides
Jan 20, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Brahm H SegalLuigina Romani
Mar 23, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Graham G NeelyChristopher H Mody
Jul 5, 2001·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·E Farmaki, E Roilides
Jan 3, 2006·American Journal of Respiratory and Critical Care Medicine·Brahm H Segal, Thomas J Walsh
Oct 16, 2004·Expert Review of Anti-infective Therapy·Oliver KayserAlbrecht F Kiderlen
Nov 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stephan R KrutzikRobert L Modlin
Dec 1, 2001·Expert Opinion on Biological Therapy·K N Masihi
Mar 21, 2006·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Silvia Bulfone-PausRalf Paus
Jan 30, 2014·Revista Da Sociedade Brasileira De Medicina Tropical·Carlos Eduardo Blanco LinaresMaria Rosa Chitolina Schetinger
Dec 2, 2010·Memórias do Instituto Oswaldo Cruz·Camila Ferreira BannwartMaria Terezinha S Peraçoli
Oct 29, 2013·International Journal of Microbiology·Saif Hameed, Zeeshan Fatima
Jul 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M UmemuraY Yoshikai
Jan 28, 2021·Journal of Fungi·Idoia BuldainAndoni Ramirez-Garcia
Jul 19, 2000·American Journal of Physiology. Heart and Circulatory Physiology·J M Dodd-O, D B Pearse
Mar 28, 2021·Microbial Pathogenesis·Grazzielle Guimarães de MatosFátima Ribeiro-Dias
Dec 19, 2007·Cytokine·Elisandra Garcia TavianAngela Maria Victoriano de Campos Soares

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.