Interleukin-15 facilitates muscle regeneration through modulation of fibro/adipogenic progenitors

Cell Communication and Signaling : CCS
Xia KangKang-Lai Tang

Abstract

Chronic muscle injury is characteristics of fatty infiltration and fibrosis. Recently, fibro/adipogenic progenitors (FAPs) were found to be indispensable for muscular regeneration while were also responsible for fibrosis and fatty infiltration in muscle injury. Many myokines have been proven to regulate the adipose or cell proliferation. Because the fate of FAPs is largely dependent on microenvironment and the regulation of myokines on FAPs is still unclear. We screened the potential myokines and found Interleukin-15 (IL-15) may regulate the fatty infiltration in muscle injury. In this study, we investigated how IL-15 regulated FAPs in muscle injury and the effect on muscle regeneration. Cell proliferation assay, western blots, qRT-PCR, immunohistochemistry, flow cytometric analysis were performed to investigate the effect of IL-15 on proliferation and adipogensis of FAPs. Acute muscle injury was induced by injection of glycerol or cardiotoxin to analyze how IL-15 effected on FAPs in vivo and its function on fatty infiltration or muscle regeneration. We identified that the expression of IL-15 in injured muscle was negatively associated with fatty infiltration. IL-15 can stimulate the proliferation of FAPs and prevent the adipog...Continue Reading

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Citations

Jan 4, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Andrew DunnKoyal Garg
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Methods Mentioned

BETA
FACS
flow cytometry
PCR

Software Mentioned

FlowJo
qPCT

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