Interleukin-16 polymorphisms as new promising biomarkers for risk of gastric cancer

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Seyed Mohammad Hossein KashfiMohammad Reza Zali

Abstract

Gastric cancer (GC) is the second cause of cancer-related death worldwide. Interleukin (IL)-16 has a vital role in the development and homeostasis of the immune system. In the present study, we evaluated an exon variant rs4072111 C/T polymorphism and 3' UTR variant rs1131445 C/T within the miRNA binding with gastric cancer susceptibility in Iranian population. Genomic DNA was isolated from peripheral blood samples according to phenol chloroform extraction. The genotypes of IL-16 polymorphisms rs1131445 T/C and rs4072111 T/C were determined by polymerase chain reaction-restriction fragment length polymorphism method. In this case control study, a total of 256 patients with gastric cancer (238 cases (92.9 %) non-cardia and 18 cases (7.1 %) cardia) and 300 healthy control subjects were evaluated. In the present study, we found a significant association between rs4072111 of IL-16 gene and risk of GC in Iranian population. Individuals with CT genotype showed a significant association with 1.79-fold increased risk of GC (P = 0.008; adjusted OR 1.792; 95 % CI 1.164-2.759). The significant association was also detected for T allele of rs4072111 and increased risk of GC (P < 0.001; adjusted OR 1.981; 95 % CI 1.354-2.900). We also observ...Continue Reading

References

Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Oct 1, 1996·Immunology Today·D M CenterW W Cruikshank
Sep 15, 2001·The New England Journal of Medicine·N UemuraR J Schlemper
Jul 29, 2003·Journal of Surgical Oncology·Yuan-Chang Chung, Ya-Fen Chang
Feb 3, 2004·American Journal of Hematology·Michael G AlexandrakisElias Castanas
Jun 4, 2004·Journal of Gastroenterology·Kyung-A LeeTae Sung Sohn
Aug 3, 2006·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·William G GlassAlfred M Del Vecchio
Jan 16, 2007·Archivum Immunologiae Et Therapiae Experimentalis·Markus LiebrichRichard Meyermann
Nov 1, 2007·Neoplasia : an International Journal for Oncology Research·Otto KollmarMichael D Menger
Feb 12, 2008·Nature Genetics·Gilles ThomasStephen J Chanock
Apr 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Frank M SpeetjensJ Fred Nagelkerke
May 20, 2008·Mutation Research·Joydeb Kumar Kundu, Young-Joon Surh
Sep 26, 2008·Inflammatory Bowel Diseases·Daniele Fina, Francesco Pallone
Oct 18, 2008·Journal of the National Comprehensive Cancer Network : JNCCN·Quan P Ly, Aaron R Sasson
Dec 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yohei HorikawaXifeng Wu
Dec 25, 2008·Expert Review of Anticancer Therapy·Philip Abraham Kovoor, Jimmy Hwang
Jul 25, 2009·Lancet·Henk H HartgrinkCornelis J H van de Velde
Sep 18, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Lin-Bo GaoLin Zhang
Mar 23, 2010·Cell·Sergei I GrivennikovMichael Karin
Mar 25, 2010·Cancer Research·Milena S NicolosoGeorge A Calin
Jun 10, 2010·International Journal of Urology : Official Journal of the Japanese Urological Association·Jian ZhuChangjun Yin
Mar 30, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marc YchouPhilippe Rougier
Jan 13, 2012·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Jan 26, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Aparna YellapaAnimesh Barua
Jun 30, 2012·Journal of the National Cancer Institute·Djordje AtanackovicNicolaus Kröger
May 29, 2013·The Journal of Experimental Medicine·Stéphanie BibertUNKNOWN Swiss Hepatitis C Cohort Study
Jun 4, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Xiong-Fei PanChun-Xia Yang
Aug 1, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiao-Feng ZengSheng-Bin Li
Oct 9, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xue QinJinmin Zhao
Nov 2, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Tao Zhang, Hui Wang
Aug 29, 2014·Genetic Testing and Molecular Biomarkers·Qi-Sheng LuoHai-Neng Huang

❮ Previous
Next ❯

Citations

Aug 4, 2016·International Journal of Immunogenetics·P AzimzadehA Shirazi
Apr 15, 2016·Scientific Reports·Kaiyuan DengJiazeng Xia
Sep 17, 2020·Oncotarget·Victor Hugo de SouzaJeane Eliete Laguila Visentainer
Nov 13, 2020·Clinical and Experimental Gastroenterology·Khadijeh Kalan FarmanfarmaHamid Salehiniya

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved