Apr 13, 2010

Interleukin-17 and its expanding biological functions

Cellular & Molecular Immunology
Sheng Xu, Xuetao Cao

Abstract

Interleukin-17 (IL-17) and IL-17-producing cells have been shown to play important roles in inflammation and the immune response. IL-17 is believed to be mainly produced by T helper 17 (Th17) cells, a unique helper T-cell subset different from Th1 and Th2 cells. Other subsets of T cells such as gammadeltaT and natural killer T (NKT) cells have also been found to produce IL-17 in response to innate stimuli. IL-17 acts as a proinflammatory cytokine that can induce the release of certain chemokines, cytokines, matrix metalloproteinases (MMPs) and antimicrobial peptides from mesenchymal and myeloid cells. This leads to the expansion and accumulation of neutrophils in the innate immune system and links innate and adaptive immunity in vivo. Furthermore, increasing evidence indicates that IL-17 and IL-17-producing cells are involved in the pathogenesis of various diseases such as allergies, autoimmune diseases, allograft transplantation and even malignancy. They may also play protective roles in host defense against infectious diseases and promote induction of cytotoxic T lymphocyte (CTL) responses against cancer. Targeting of the IL-17 axis is under investigation for the treatment of inflammatory disorders.

  • References118
  • Citations66
  • References118
  • Citations66

Citations

Mentioned in this Paper

Immune Response
Pathogenic Aspects
Immune System
T-Lymphocyte
Pathogenesis
Interleukin-17 Receptor E
Cytotoxic T-Lymphocytes
Neutrophils as Percentage of Blood Leukocytes (Lab Test)
Interleukin-17B
Recombinant Interleukin-17

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