Abstract
Interleukin 17 (IL-17) is produced by T(H)17 cells and was recently implicated in the development of the T(H)2 cell response. RANTES (regulated on activation of normal T cells expressed and secreted), among other chemokines, plays a crucial role in chemotaxis of eosinophils into airway mucosa. According to the "united airway" hypothesis, markers of inflammation in allergic diseases are elevated in the upper and lower airways. To assess the impact of a single nasal allergen challenge on IL-17 and RANTES levels in induced sputum of patients with allergic rhinitis (AR). Eighteen patients with a history of AR due to grass pollen confirmed by positive skin prick test results and 10 control subjects entered the study. Initially, all the patients underwent sputum induction. A single nasal placebo challenge was performed 24 hours later, with repeated sputum induction 24 hours after challenge. After 4 weeks of washout, these procedures were repeated with allergen challenge. Differential cell counts in sputum were determined, and concentrations of IL-17 and RANTES were measured by means of enzyme-linked immunosorbent assay. Levels of IL-17 and RANTES significantly increased in sputum of patients with AR after allergen (but not placebo) c...Continue Reading
References
Feb 1, 1992·The Journal of Allergy and Clinical Immunology·J CorrenC G Irvin
Dec 1, 1991·The American Review of Respiratory Disease·J B SedgwickW W Busse
Feb 1, 1997·American Journal of Respiratory and Critical Care Medicine·K RajakulasingamS R Durham
Jan 1, 1997·Allergy·S Pedersen, P O'Byrne
Jul 1, 1997·The Journal of Allergy and Clinical Immunology·A ForesiD Olivieri
Mar 9, 1999·The Journal of Allergy and Clinical Immunology·A KleinJanW J Fokkens
Aug 3, 1999·American Journal of Respiratory and Critical Care Medicine·G M GauvreauP M O'Byrne
Sep 1, 2000·The European Respiratory Journal·M PurokiviH Tukiainen
May 30, 2002·American Journal of Respiratory Cell and Molecular Biology·Carol E Jones, Katie Chan
Oct 2, 2002·Immunity·Susumu NakaeYoichiro Iwakura
Apr 12, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K M BeehR Buhl
Jul 23, 2003·Clinical Otolaryngology and Allied Sciences·R J SalibP H Howarth
Dec 4, 2004·The Journal of Allergy and Clinical Immunology·Mio KawaguchiShau-Ku Huang
Jan 8, 2005·The Journal of Allergy and Clinical Immunology·Gert-Jan Braunstahl
Oct 4, 2005·Nature Immunology·Heon ParkChen Dong
Oct 4, 2005·Nature Immunology·Laurie E HarringtonCasey T Weaver
Nov 4, 2005·Allergy·E M ErinT T Hansel
Dec 21, 2005·Allergy·M BonayM Aubier
Feb 9, 2006·European Journal of Pharmacology·Joost J Smit, Nicholas W Lukacs
Sep 22, 2007·Allergy and Asthma Proceedings·Christine KlemensMatthias F Kramer
Jul 8, 2008·The Journal of Allergy and Clinical Immunology·Giorgio CiprandiGilberto Filaci
Feb 20, 2009·Allergy·G CiprandiM Tosca
Citations
Nov 7, 2012·Asia Pacific Allergy·Jae-Woo KwonHeung-Woo Park
Dec 29, 2013·Journal of Immunological Methods·Julia HentschelJochen G Mainz
Apr 18, 2012·Human Immunology·Min WangLuo Zhang
Jul 31, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M WangC Bachert
Jan 24, 2014·International Immunopharmacology·Rong JinJian-hua Zhang
Aug 22, 2018·Oncology Letters·Qiping ShiHaiying Jia
Aug 19, 2014·Journal of Inflammation·Adam BarczykIan M Adcock