Interleukin-17 Could Promote Breast Cancer Progression at Several Stages of the Disease

Mediators of Inflammation
Thomas Welte, Xiang H-F Zhang

Abstract

Metastatic disease accounts for more than 90% of deaths from breast cancer. Yet the factors that trigger metastasis, often years after primary tumor removal, are not understood well. Recently the proinflammatory cytokine interleukin- (IL-) 17 family has been associated with poor prognosis in breast cancer. Here we review current literature on the pathogenic mechanisms driven by IL-17 during breast cancer progression and connect these findings to metastasis. These include (1) direct effects of IL-17 on tumor cells promoting tumor cell survival and invasiveness, (2) regulation of tumor angiogenesis, and (3) interaction with myeloid derived suppressor cells (MDSCs) to inhibit antitumor immune response and collaborate at the distant metastatic site. Furthermore, IL-17 might also be a culprit in bone destruction caused by late stage bone metastasis. Interestingly, in addition to these potential prometastasis functions, there is also evidence for an opposite, antitumor role of IL-17 during cancer therapies. We hypothesize that these contradictory roles may be due to chronic, imbalanced versus acute transient nature of the immune reactions, as well as differences in the cells that interact with IL-17(+) cells under different circumsta...Continue Reading

References

Oct 6, 2001·American Journal of Respiratory Cell and Molecular Biology·P YeJ K Kolls
Oct 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christina L RoarkRebecca L O'Brien
Mar 21, 2008·Cancer Immunology, Immunotherapy : CII·Tania BenatarAiping H Young
Apr 16, 2008·The Journal of Experimental Medicine·Xuexian O YangChen Dong
Aug 1, 2009·Breast Cancer Research : BCR·Lopamudra Das RoyPinku Mukherjee
Aug 28, 2009·The New England Journal of Medicine·Pierre MiossecVijay K Kuchroo
Dec 17, 2009·Cancer Immunology, Immunotherapy : CII·Tania BenatarAiping H Young
Dec 23, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xinming SuGuangyong Peng
Sep 30, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James N IngleRichard M Weinshilboum
Dec 24, 2010·Virulence·Shabaana A Khader, Radha Gopal
Feb 26, 2011·Immunity·Yoichiro IwakuraSusumu Nakae
Mar 9, 2011·The Journal of Experimental Medicine·Yuting MaLaurence Zitvogel
Apr 15, 2011·Science Translational Medicine·Saori FurutaWen-Hwa Lee
Nov 15, 2011·FEMS Immunology and Medical Microbiology·Thomas WelteTian Wang
Nov 22, 2011·European Journal of Immunology·Radha GopalShabaana A Khader
Mar 13, 2012·Cancer Discovery·Sergey V NovitskiyHarold L Moses
Dec 7, 2013·European Journal of Immunology·Geng Bian, Wen-Ying Zhao
Jun 20, 2014·Immunological Reviews·Jeremy P McAleer, Jay K Kolls

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Citations

Sep 11, 2016·Pharmacology & Therapeutics·K-S N AtretkhanyD V Kuprash
Mar 7, 2018·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Benelita T ElieMaría Contel
Mar 2, 2018·Journal of Leukocyte Biology·Guillaume P AndrieuGerald V Denis
Jan 11, 2018·Journal of Translational Medicine·Yijing ZhaoJiuwei Cui
Oct 31, 2019·International Journal of Molecular Sciences·Alina-Andreea ZimtaIoana Berindan-Neagoe
Aug 6, 2016·Cellular and Molecular Life Sciences : CMLS·Dequina A NicholasGerald V Denis
May 19, 2019·Clinical and Experimental Medicine·Guadalupe Avalos-NavarroAlicia Del Toro-Arreola
Aug 5, 2017·Analytical Cellular Pathology (Amsterdam)·Nadine GelbrichMatthias B Stope
Dec 7, 2018·International Journal of Molecular Sciences·Joseph Antoine Salvator FabreArmand Bensussan
Jan 16, 2019·BMC Cancer·Niloofar KhodabandehlouMohsen Moghoofei
Mar 6, 2021·Frontiers in Immunology·Yang LiXi Chen

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Methods Mentioned

BETA
biopsy

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