Interleukin 17 (IL-17)-Induced Mesenchymal Stem Cells Prolong the Survival of Allogeneic Skin Grafts

Annals of Transplantation : Quarterly of the Polish Transplantation Society
Tengxiao MaDuyin Jiang

Abstract

BACKGROUND Mesenchymal stem cells (MSCs) have the potential of self-renewal and multi-differentiation and have a wide application prospect in organ transplantation for the effect of inducing immune tolerance. It has found that interleukin 17 (IL-17) could enhance the inhibition effect of MSCs on T cell proliferation and increase the immunosuppressive effect of MSCs. In this study, we aimed to investigate the effect of IL-17-induced MSCs on allograft survival time after transplantation. MATERIAL AND METHODS BMSCs were characterized by differential staining. The allogenic skin transplantations were performed and the BMSCs pre-treated by IL-17 were injected. To assess the immunosuppressive function of IL-17-induced BMSCs, the morphology of the grafts, the homing ability of the BMSCs, and the survival time of the grafts were analyzed. RESULTS BMSCs from BALB/c have multidirectional differentiation potential to differentiate into osteogenic, chondrogenic, and adipogenic lineage cells. IL-17-induced BMSCs prolonged the survival time of allogeneic skin grafts dramatically. We found that there were more labeled MSCs in the skin grafts, and the Treg subpopulations percentage, IL-10, and TGF-β were significantly increased, while the IFN-...Continue Reading

Citations

Jun 18, 2019·Journal of Cellular and Molecular Medicine·Yi TanShan Zhao
Jan 18, 2020·Journal of Clinical Medicine·Greg HutchingsHanna Piotrowska-Kempisty
Aug 30, 2020·Inflammation·Lucas Buzeli de SouzaThiago Antônio Moretti de Andrade
Oct 10, 2020·World Journal of Stem Cells·Aleksandra JaukovićDiana Bugarski
Mar 14, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Wee-Song Yeo, Qin Xiang Ng

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Methods Mentioned

BETA
xenografts
xenograft
ELISA
flow cytometry

Software Mentioned

SPSS
GraphPad

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