Interleukin-17 produced by tumor microenvironment promotes self-renewal of CD133+ cancer stem-like cells in ovarian cancer

Oncogene
Tong XiangBo Zhu

Abstract

Inflammatory cytokines, components of cancer stem cells (CSCs) niche, could affect the characteristics of CSCs such as self-renewal and metastasis. Interleukin-17 (IL-17) is a new pro-inflammatory cytokine mainly produced by T-helper (Th17) cells and macrophages. The effects of IL-17 on the characteristics of CSCs remain to be explored. Here we first demonstrated a role of IL-17 in promoting the self-renewal of ovarian CD133(+) cancer stem-like cells (CSLCs). We detected IL-17-producing cells (CD4(+) cells and CD68(+) macrophages) in the niche of CD133(+)CSLCs. Meanwhile, there was IL-17 receptor expression on CD133(+)CSLCs derived from A2780 cell line and primary ovarian cancer tissues. By recombinant human IL-17 stimulation and IL-17 transfection, the growth and sphere formation capacities of ovarian CD133(+)CSLCs were significantly enhanced in a dose-dependent manner. Moreover, ovarian CD133(+)CSLCs transfected with IL-17 showed greater tumorigenesis capacity in nude mice. These data suggest that IL-17 promoted the self-renewal of ovarian CD133(+)CSLCs. Further investigation through gene profiling revealed that the stimulation function of IL-17 on self-renewal of ovarian CD133(+)CSLCs might be mediated by the nuclear factor ...Continue Reading

References

May 21, 1999·Biochemical and Biophysical Research Communications·S V SubramaniamS E Adunyah
Aug 17, 1999·Biochemical and Biophysical Research Communications·S V SubramaniamS E Adunyah
Sep 13, 2000·Molecular Cell·J LaineM Noguchi
Jun 13, 2001·Biochemical and Biophysical Research Communications·T KatoT Aono
Apr 30, 2005·Immunology Letters·Hidenori TakahashiHidetada Sasaki
Oct 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Muneo NumasakiHidetada Sasaki
Oct 13, 2006·The Journal of Biological Chemistry·Seon Hee ChangChen Dong
Oct 26, 2006·Breast Cancer Research : BCR·Carol SheridanHarikrishna Nakshatri
Jun 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Karen Sandell SfanosCharles G Drake
Jul 25, 2008·Nature·Alberto MantovaniFrances Balkwill
Oct 4, 2008·Proceedings of the National Academy of Sciences of the United States of America·Yoshihiro MiyaharaRong-Fu Wang
Sep 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gopal Murugaiyan, Bhaskar Saha
Jan 7, 2010·The Journal of Clinical Investigation·Christophe GinestierMax S Wicha
May 18, 2010·International Journal of Cancer. Journal International Du Cancer·Claire VillalvaLucie Karayan-Tapon
Jun 10, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Catherine Adell O'BrienCatriona H M Jamieson
Nov 26, 2010·Nature·Rong WangViviane Tabar
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Aug 27, 2011·Breast Cancer Research : BCR·Kateryna Shostak, Alain Chariot
Nov 2, 2011·Journal of the National Cancer Institute·Sandy AzziPierre Eid
Nov 29, 2011·Cancer Immunology, Immunotherapy : CII·Dongmei LaiLihe Guo
Oct 20, 2012·Biochimica Et Biophysica Acta·Alina FilatovaBoyan K Garvalov
Jul 11, 2013·Nature Communications·Silvia DomckeNikolaus Schultz
Sep 3, 2013·Nature Neuroscience·Zizhen KangXiaoxia Li

❮ Previous
Next ❯

Citations

Mar 29, 2014·Journal of Medicinal Chemistry·Catherine M ClavelPaul J Dyson
Mar 17, 2016·Mediators of Inflammation·Bruno SainzHeather L Machado
Jan 16, 2015·International Journal of Molecular Sciences·Doxakis AnestakisAthanasios Salifoglou
Dec 20, 2015·European Journal of Medical Research·Ping ZhouYongfei Wang
Jun 17, 2015·Journal of Cell Communication and Signaling·Jyoti SharmaAkhilesh Pandey
Apr 9, 2016·Cells·Amanda L Rinkenbaugh, Albert S Baldwin
Aug 16, 2015·Cancer Letters·Lanlan Hui, Ye Chen
Mar 6, 2015·Pathology Oncology Research : POR·José Veríssimo FernandesJosélio Maria Galvão de Araújo
Aug 15, 2018·International Journal of Molecular Sciences·Yi-Heng LinYen-Hua Huang
Nov 13, 2018·Journal of Cellular Physiology·Masoud NajafiKeywan Mortezaee
Dec 23, 2016·Nature Cell Biology·Emily M Hatch
Nov 16, 2019·The Journal of Experimental Medicine·Junjie ZhaoXiaoxia Li
Nov 16, 2019·The Journal of Experimental Medicine·Gerardo A Vitiello, George Miller
Jan 26, 2017·Oncotarget·Saswati KarmakarMoorthy P Ponnusamy
Jun 10, 2020·Investigative Ophthalmology & Visual Science·Satoshi HiroseHomayon Ghiasi
Mar 13, 2019·Infectious Agents and Cancer·Kasper IngerslevJan Blaakaer
Aug 19, 2017·Stem Cells International·Manuel Varas-GodoySebastián E Illanes
Aug 10, 2017·Oncology Letters·Xiaohui XieJianlin Chen
Mar 12, 2020·Immune Network·Da-Sol KuenYeonseok Chung
Aug 18, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Elena AndreucciLido Calorini
Dec 18, 2018·Frontiers in Immunology·Diana P SaraivaM Guadalupe Cabral
Mar 3, 2020·Frontiers in Immunology·Luise MüllerMarc Schmitz
Jul 3, 2018·Oncology Letters·Shijian ZhangChenping Zhang
Jun 6, 2018·Frontiers in Oncology·Norashikin ZakariaBadrul Hisham Yahaya

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.