Interleukin-17-producing decidual CD4+ T cells are not deleterious for human pregnancy when they also produce interleukin-4

Clinical and Molecular Allergy : CMA
Letizia LombardelliM P Piccinni

Abstract

Trophoblast expressing paternal HLA-C antigens resemble a semiallograft, and could be rejected by maternal CD4+ T lymphocytes. We examined the possible role in human pregnancy of Th17 cells, known to be involved in allograft rejection and reported for this reason to be responsible for miscarriages. We also studied Th17/Th1 and Th17/Th2 cells never investigated before. We defined for the first time the role of different Th17 subpopulations at the embryo implantation site and the role of HLA-G5, produced by the trophoblast/embryo, on Th17 cell differentiation. Cytokine production by CD4+ purified T cell and T clones from decidua of normal pregnancy, unexplained recurrent abortion, and ectopic pregnancy at both embryo implantation site and distant from that site were analyzed for protein and mRNA production. Antigen-specific T cell lines were derived in the presence and in the absence of HLA-G5. We found an associated spontaneous production of IL-17A, IL-17F and IL-4 along with expression of CD161, CCR8 and CCR4 (Th2- and Th17-type markers) in fresh decidua CD4+ T cells during successful pregnancy. There was a prevalence of Th17/Th2 cells (producing IL-17A, IL-17F, IL-22 and IL-4) in the decidua of successful pregnancy, but the ex...Continue Reading

References

Aug 1, 1991·Immunology Today·S Romagnani
Jul 1, 1995·Journal of Clinical Immunology·M Suthanthiran, T B Strom
Oct 1, 1996·Current Opinion in Immunology·T B StromA Bushell
Aug 3, 1999·American Journal of Reproductive Immunology : AJRI·S FournelP Le Bouteiller
Feb 10, 2000·Springer Seminars in Immunopathology·U SyrbeA Hamann
Apr 4, 2001·The Journal of Clinical Investigation·A M WaagaM H Sayegh
Mar 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Aliz BarakonyiJulia Szekeres-Bartho
Jun 19, 2002·The Journal of Experimental Medicine·Luis GracaHerman Waldmann
Dec 10, 2003·The Journal of Experimental Medicine·Craig A MurphyDaniel J Cua
May 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·William R BurnsGeorge Tellides
Sep 7, 2005·Immunology Letters·John PappasNamit Ghildyal
May 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jakob MichaëlssonDouglas F Nixon
Jan 2, 2007·Proceedings of the National Academy of Sciences of the United States of America·Marinos KallikourdisAlexander G Betz
May 9, 2007·Nature Immunology·Eva V Acosta-RodriguezGiorgio Napolitani
Jul 20, 2007·The Journal of Experimental Medicine·Francesco AnnunziatoSergio Romagnani
Jul 30, 2008·The Journal of Experimental Medicine·Lorenzo CosmiFrancesco Annunziato
Aug 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hicham El CostaJulie Tabiasco
Dec 3, 2008·The Journal of Experimental Medicine·Xueli YuanM Javeed Ansari
Jan 3, 2009·Immunity·Yun Kyung LeeCasey T Weaver
Jan 9, 2009·European Journal of Immunology·Veronica SantarlasciFrancesco Annunziato
Mar 11, 2009·The Journal of Experimental Medicine·Melanie A KleinschekRobert A Kastelein
Apr 11, 2009·Transplant Immunology·Haiyong ChenShusen Zheng
Jan 30, 2010·The Journal of Allergy and Clinical Immunology·Lorenzo CosmiFrancesco Annunziato
Mar 26, 2010·Journal of Reproductive Immunology·Marie-Pierre Piccinni
Nov 9, 2010·BJOG : an International Journal of Obstetrics and Gynaecology·S S WitkinD Skupski
Mar 14, 2013·American Journal of Reproductive Immunology : AJRI·Sarah A RobertsonLachlan M Moldenhauer
Sep 3, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Letizia LombardelliMarie-Pierre Piccinni
Jul 22, 2014·European Journal of Immunology·Francesco ColucciJohn Trowsdale

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Citations

Sep 22, 2016·Clinical and Molecular Allergy : CMA·Marie-Pierre PiccinniSergio Romagnani
Nov 15, 2017·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Danny L G FagundesAdenilda C Honorio-França
Feb 28, 2018·Clinical & Translational Immunology·Barbara PoleseVincent Geenen
Mar 25, 2019·American Journal of Reproductive Immunology : AJRI·Jinlu JiAihua Liao
May 30, 2020·Cellular & Molecular Immunology·Derek MillerNardhy Gomez-Lopez
Aug 26, 2020·HLA : Immune Response Genetics·Michael EikmansSebastiaan Heidt
Aug 7, 2018·Frontiers in Immunology·Janri GeldenhuysMarleen Magdalena Kock
May 22, 2021·Journal of Autoimmunity·Jonathon J GrahamMichael A Heneghan
Aug 17, 2021·Frontiers in Immunology·Marie-Pierre PiccinniJulia Szekeres-Bartho
Sep 21, 2021·Experimental and Therapeutic Medicine·Aida PetcaMona Elena Zvanca

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Methods Mentioned

BETA
biopsies
FCS
PMA
transfectant
flow cytometry

Software Mentioned

SSPS
Bioplex200
FACSDiva
BD
Biosciences
SPSS

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