Interleukin-17-producing T helper cells in autoimmunity

Autoimmunity Reviews
Nasr Y A HemdanUlrich Sack

Abstract

With all the incredible progress in scientific research over the past two decades, the trigger of the majority of autoimmune disorders remains largely elusive. Research on the biology of T helper type 17 (T(H)17) cells over the last decade not only clarified previous observations of immune regulations and disease manifestations, but also provided considerable information on the signaling pathways mediating the effects of this lineage and its seemingly dual role in fighting the invading pathogens on one hand, and in frightening the host by inducing chronic inflammation and autoimmunity on the other hand. In this context, recent reports have implicated T(H)17 cells in mediating host defense as well as a growing list of autoimmune diseases in genetically-susceptible individuals. Herein, we summarize the current knowledge on T(H)17 in autoimmunity with emphasis on its differentiation factors and some mechanisms involved in initiating pathological events of autoimmunity.

References

Mar 1, 1987·Annales De L'Institut Pasteur. Immunology·J F BrunetP Golstein
Mar 20, 1998·International Reviews of Immunology·T Hirano
Jul 3, 1999·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·J T Cross, H P Benton
Jun 7, 2000·Proceedings of the National Academy of Sciences of the United States of America·S B WilsonM C Byrne
Nov 21, 2000·The Journal of Experimental Medicine·W W HancockC Gerard
Nov 15, 2002·Molecular Immunology·Sean Diehl, Mercedes Rincón
Dec 4, 2002·Nature Reviews. Immunology·Kenneth M Murphy, Steven L Reiner
Dec 26, 2002·Annual Review of Immunology·Susanne J SzaboLaurie H Glimcher
Dec 10, 2003·The Journal of Experimental Medicine·Craig A MurphyDaniel J Cua
Mar 26, 2005·Proceedings of the National Academy of Sciences of the United States of America·Estelle BettelliMohamed Oukka
Jun 24, 2006·Trends in Immunology·Marc Veldhoen, Brigitta Stockinger
Sep 20, 2006·The Journal of Experimental Medicine·Spencer C LiangLynette A Fouser
Feb 6, 2007·The Journal of Biological Chemistry·Xuexian O YangChen Dong
Feb 9, 2007·The New England Journal of Medicine·Gerald G KruegerUNKNOWN CNTO 1275 Psoriasis Study Group
Feb 10, 2007·Autoimmunity Reviews·Janette Furuzawa-CarballedaAntonio R Cabral
Jun 1, 2007·Journal of the American Society of Nephrology : JASN·Ulf PanzerRolf A K Stahl
Jun 30, 2007·Journal of Internal Medicine·B T Rouse
Jun 30, 2007·The American Journal of Pathology·Cecelia C YatesAlan Wells
Jul 20, 2007·Genes & Development·Brooke AncrileChristopher M Counter
Sep 6, 2007·Annals of the New York Academy of Sciences·Nasr Y A HemdanUlrich Sack
Oct 6, 2007·European Journal of Immunology·Massimo C FantiniGiovanni Monteleone

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Citations

Feb 22, 2011·Clinical Reviews in Allergy & Immunology·Cees G M Kallenberg
Dec 29, 2011·Clinical Reviews in Allergy & Immunology·Yehuda Shoenfeld
Oct 12, 2012·Clinical Reviews in Allergy & Immunology·Nancy Agmon-Levin, Carlo Selmi
Jul 10, 2012·Nature Medicine·Ruozhen Hu, Ryan M O'Connell
Oct 24, 2012·Journal of Biomedicine & Biotechnology·Junwei ChenXiaofeng Li
Aug 27, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Linda M McAllister-LucasPeter C Lucas
Oct 20, 2012·Arthritis Research & Therapy·Benjamin WildeJan Willem Cohen Tervaert
Nov 22, 2013·Toxins·Alexander MunzerHubertus Himmerich
Nov 2, 2012·Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders·Yasuhiro ShimojimaShu-Ichi Ikeda
Mar 10, 2012·Immunotherapy·Carlo Perricone, Roberto Perricone
Oct 8, 2011·Bioscience, Biotechnology, and Biochemistry·Tadaomi Kawashima
Mar 29, 2013·Autoimmunity Reviews·Smadar Gertel-LapterMiriam C Souroujon
Aug 26, 2014·Autoimmunity Reviews·Gilad Halpert, Benjamin Sredni
Mar 8, 2013·Genes and Immunity·A OvadiaY Shinar
Sep 2, 2011·Stem Cell Reviews and Reports·Ênio José BassiNiels Olsen Saraiva Câmara
Feb 9, 2016·Autoimmunity Reviews·Anantha Maharasi RamaKrishnan, Kavitha Sankaranarayanan
Sep 27, 2014·European Journal of Immunology·Eva Kolwijck, Frank L van de Veerdonk
Jul 19, 2011·Autoimmunity Reviews·Carlo Selmi
Apr 16, 2011·Trends in Immunology·Jarod ZeppXiaoxia Li
Feb 16, 2011·Autoimmunity Reviews·Yu-Tsan LinBor-Luen Chiang
Jan 5, 2011·Autoimmunity Reviews·Rossana ScrivoGuido Valesini
Mar 2, 2016·Cytokine·Ceyla Konca DegertekinMetin Arslan
Jan 21, 2016·Mediators of Inflammation·Fabiana NevesPedro J Esteves
May 20, 2015·Hämostaseologie·Tamam Bakchoul, Ulrich J Sachs
Nov 8, 2013·Journal of Neuroimmunology·Diane A TurnerFabrizio Giuliani
May 17, 2013·Seminars in Hematology·Dana YehudaiZahava Vadasz
Mar 20, 2013·International Immunopharmacology·Jinhui HuHongxing Ye
Feb 16, 2015·Clinical Reviews in Allergy & Immunology·Ying SunM Eric Gershwin

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