Interleukin-18: a regulator of cancer and autoimmune diseases

European Cytokine Network
Maryam Esmailbeig, Abbas Ghaderi

Abstract

Interleukin (IL)-18, structurally similar to IL-1β, is a member of IL-1 superfamily of cytokines. This cytokine, which is expressed by many human lymphoid and nonlymphoid cells, has an important role in inflammatory processes. The main function of IL-18 is mediated through induction of interferon-γ (IFN-γ) secretion from T helper (Th1) cells. This cytokine synergistically with IL-12 contributes to Th1 differentiation and, therefore, is important in host defense mechanisms against intracellular bacteria, viruses, and fungi. Recent evidences showing the involvement of IL-18 in Th2 differentiation and ultimately IgE production from B cells have shed a new insight on the dual effects of IL-18 on Th1 and Th2 inflammatory responses. IL-18 in combination with IL-12 can activate cytotoxic T cells (CTLs), as well as natural killer (NK) cells, to produce IFN-γ and, therefore, may contribute to tumor immunity. The biological activity of IL-18 is not limited to these cells, but it also plays a role in development of Th17 cell responses. IL-18 synergistically with IL-23 can induce IL-17 secretion from Th17 cells. The diverse biological activity of IL-18 on T-cell subsets and other immune cells has made this cytokine a good target for invest...Continue Reading

Citations

Nov 26, 2019·Journal of Pediatric Hematology/oncology·Hossein SolatiZahra Amirghofran
Oct 6, 2020·Journal of Immunology Research·Liliana R BalahuraMarieta Costache
Jan 14, 2020·Biochemical Pharmacology·Tao YuJae Youl Cho
Mar 23, 2021·Biochimie·Xiaoli JuQiang Wang
Sep 21, 2021·Thyroid : Official Journal of the American Thyroid Association·Anello Marcello PomaFulvio Basolo

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