Interleukin-18 and interferon-gamma polymorphisms are implicated on proviral load and susceptibility to human T-lymphotropic virus type 1 infection

Tissue Antigens
Maurício Cristiano Rocha-JuniorSimone Kashima

Abstract

Interleukin-18 (IL-18) and interferon-gamma (IFN-γ) exert important functions in both innate and adaptive immune responses against intracellular pathogens and viruses. Previous studies suggested that host genetic factors, including cytokines gene polymorphisms, could be involved in the pathogenesis of human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Thus, we analyzed -137C/G and -607A/C of the IL-18 promoter and +874T/A of the IFN-γ in DNA samples from 98 HTLV-1-infected individuals exhibiting or not clinical symptoms and 150 healthy control individuals. The IL-18 promoter -607CC genotype was significantly lower in HTLV-1 asymptomatic carriers (HAC) and HTLV-1-infected individuals (HAC + HAM/TSP) than healthy control group. In contrast, the -607AC genotype was significantly higher in HAC and HTLV-1-infected individuals group compared to the healthy control group. The -137G/-607A IL-18 haplotype was higher in infected group than healthy control group, and the -137C/-607C IL-18 haplotype was increased in the healthy control group compared to the others. Finally, the IFN-γ polymorphism analysis showed that the HTLV-1-infected individuals with +874AT genotype presented higher...Continue Reading

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Citations

Nov 21, 2014·Memórias do Instituto Oswaldo Cruz·Anselmo Jiro KamadaLucas André Cavalcanti Brandão
Aug 31, 2017·Annual Review of Genetics·Adam D KenneyJacob S Yount
Oct 28, 2019·Viruses·Antonio Carlos Rosário VallinotoRicardo Ishak
Jun 6, 2018·Frontiers in Microbiology·Maria A F QueirozRosimar N Martins Feitosa
Dec 22, 2019·Viruses·Denis de Castro SilvaMaria Alice Freitas Queiroz
Jul 30, 2014·Genetics and Molecular Biology·Wenna Gleyce Araújo do NascimentoJanaina Cristiana de Oliveira Crispim
Jul 14, 2021·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Carlos BritesAntonio Carlos Rosário Vallinoto

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