Interleukin-18 attenuates disruption of brain-blood barrier induced by status epilepticus within the rat piriform cortex in interferon-γ independent pathway

Brain Research
Hyung Keon JungTae-Cheon Kang

Abstract

Status epilepticus increases brain-blood barrier (BBB) permeability leading to vasogenic edema. This BBB disruption is usually confined within relatively limited cerebral regions including the piriform cortex (PC), and leads to epileptogenesis and contributes to progression of epilepsy. Although cytokines are at least partly responsible for changes in BBB permeability, the role of interleukin-18 (IL-18) in vasogenic edema is not yet explored in detail. In the present study, we investigated the role of IL-18 in SE-induced vasogenic edema formation. Following SE, IL-18/interferon-γ (IFN-γ) system was up-regulated in astrocytes and microglia/macrophages. Recombinant rat (rr) IL-18 infusion decreased vasogenic edema formation, while anti-rat IL-18 infusion increased it. In contrast, rrIFN-γ, and anti-rat IFN-γ infusion showed reverse effects on vasogenic edema formation. rrIL-18 or anti-rat IFN-γ IgG infusion elevated dystrophin expression accompanied by the reduction in vasogenic edema. However, rr-IFN-γ or anti-rat IL-18 IgG infusion significantly decreased dystrophin immunoreactivity within the PC following SE. These findings indicate that IL-18-mediated up-regulation of dystrophin expression may play either a direct or indirect...Continue Reading

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Citations

Mar 8, 2014·Brain, Behavior, and Immunity·Silvia AlboniFabio Tascedda
Jan 8, 2018·Reviews in the Neurosciences·Elena D OsipovaAlla B Salmina
Feb 12, 2014·Journal of Cellular Physiology·Jikui ShenPeter A Campochiaro
Jul 12, 2019·Frontiers in Immunology·Erin Fahey, Sarah L Doyle
Mar 17, 2021·Clinical Reviews in Allergy & Immunology·Márta L DebreczeniLászló Cervenak
Jul 14, 2020·Seizure : the Journal of the British Epilepsy Association·Monika MocholSigrid Svalheim
Jan 12, 2022·Molecular Neurobiology·Alireza Soltani KhaboushanNima Rezaei

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