Interleukin-18 enhances breast cancer cell migration via down-regulation of claudin-12 and induction of the p38 MAPK pathway

Biochemical and Biophysical Research Communications
Yoolhee YangDaeho Cho

Abstract

Interleukin-18 (IL-18) was recently reported to have a pro-tumor effect in various cancers. Increased IL-18 levels in the serum of cancer patients correlated with malignancy, and IL-18 acts a crucial factor for cell migration in gastric cancer and melanoma. Claudins, which are the most important tight junction proteins, are also linked with cancer progression and metastasis. However, the relationship between claudins and IL-18 is not well-understood. Here, we show that the migratory ability of MCF-7 cells was reduced when endogenous IL-18 expression was inhibited with IL-18 siRNA. Moreover, exogenous IL-18 enhanced breast cancer cell migration and suppressed the expression of the tight junction proteins claudin-1, claudin-3, claudin-4, and claudin-12 in MCF-7 cells. Knockdown of claudin-3, claudin-4, and claudin-12, but not claudin-1, increased breast cancer migration with maximal effects observed in claudin-12 siRNA-transfected cells. To investigate whether the mitogen-activated protein kinase (MAPK) signaling pathway is involved in IL-18-induced cell migration and claudin-12 expression, cells were pretreated with SB203580 (an inhibitor of p38 MAPK) or PD98059 (an inhibitor of ERK1/2) prior to the addition of IL-18. Although p...Continue Reading

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Citations

Jun 1, 2016·Pathogens and Disease·Laure AurelianAric Colunga
Mar 2, 2016·Journal of Clinical Pathology·Omid IravaniBoon-Huat Bay
Apr 8, 2017·Journal of Molecular Endocrinology·Natalia CalvoClaudia Gentili
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Aug 6, 2016·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Elaine D PorHeuy-Ching Wang
Jun 25, 2019·Frontiers in Immunology·Kevin J BakerElizabeth Brint
Feb 20, 2020·Military Medicine·Alakesh BeraMeera Srivastava
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Jul 25, 2021·Cancers·Xiuxia LuXing Zhang

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