Interleukin-18, Functional IL-18 Receptor and IL-18 Binding Protein Expression in Active and Latent Tuberculosis

Pathogens
Sebastian WawrockiMagdalena Druszczynska

Abstract

A thorough understanding of the processes modulating the innate and acquired immune response to Mycobacterium tuberculosis (M.tb) infection in the context of gene expression is still a scientific and diagnostic problem. The study was aimed to assess IL-18, IL-18 binding protein (IL-18BP), IL-18R, IFN-γ, and IL-37 mRNA expression in patients with active tuberculosis (ATB) and healthy volunteers with latent M.tb-infection (LTB) or M.tb-uninfected healthy controls (Control). The relative mRNA expression was assessed in the buffy coat blood fraction using the qPCR method. In total, 97 BCG-vaccinated Polish adults were enrolled in the study. The relative expression of IL-18 and IL-18BP mRNA was significantly elevated in the ATB and LTB groups. In ATB, but not LTB individuals, the overexpression of IL-18 and IL-18BP, as well as a significant increase in IFN-γ mRNA expression, might be considered as a manifestation of active tuberculosis disease. No statistically significant differences were observed in the IL-37 mRNA expression among the studied groups. Particularly noteworthy is the outstanding reduction in the relative expression of IL-18R mRNA in the LTB group as compared to the ATB and Control group. Reduced expression of IL-18R ...Continue Reading

References

Mar 1, 1983·The Journal of Experimental Medicine·S L NaylorP W Gray
Mar 1, 1997·American Journal of Respiratory and Critical Care Medicine·R A TahaQ Hamid
Mar 13, 2001·Annual Review of Immunology·K NakanishiH Okamura
Jan 30, 2003·Journal of Leukocyte Biology·J Alastair GracieIain B McInnes
Dec 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ralf GutzmerThomas Werfel
Mar 9, 2004·Postȩpy higieny i medycyny doświadczalnej·Marek Fol, Teresa Gościcka
Jun 19, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alexandre S AlmeidaJohn L Ho
Dec 2, 2009·European Journal of Immunology·Bianca E SchneiderUlrich E Schaible
Oct 12, 2010·Nature Immunology·Marcel F NoldCharles A Dinarello
Jan 15, 2011·Clinical & Developmental Immunology·Suhail Ahmad
Jan 6, 2012·Clinical and Vaccine Immunology : CVI·Yuzo SuzukiKingo Chida
Feb 1, 2012·The Journal of International Medical Research·Y B WangY Zhang
Oct 12, 2013·Frontiers in Immunology·Charles A DinarelloGilles Kaplanski
Nov 28, 2013·Seminars in Immunology·Daniela NovickCharles A Dinarello
Oct 21, 2014·Expert Review of Clinical Immunology·Shannon Quirk, Devendra K Agrawal
Feb 18, 2016·Acta biochimica Polonica·Sebastian WawrockiWieslawa Rudnicka
Apr 12, 2016·European Journal of Immunology·Charles A DinarelloPhilip Bufler
Nov 7, 2016·Biochemical and Biophysical Research Communications·Mengmeng ZhaoTianshu Yang
Oct 12, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Clement G Adu-GyamfiMelinda S Suchard
Dec 20, 2017·Proceedings of the National Academy of Sciences of the United States of America·Uma S GautamSmriti Mehra
Dec 28, 2017·PloS One·Magdalena DruszczynskaWieslawa Rudnicka
Dec 6, 2018·Tuberculosis·Krishnamohan AtmakuriHazel M Dockrell
Jul 14, 2019·Acta biochimica Polonica·Sebastian WawrockiMagdalena Druszczynska
Jan 10, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yong HuangWei Wang
Jan 10, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yu PanXian Jiang

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Software Mentioned

BioRad
Quantity One
GeNorm
GraphPad Prism
MedCalc

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.