Interleukin-18 gene polymorphisms and risk of recurrent pregnancy loss: A systematic review and meta-analysis

The Journal of Obstetrics and Gynaecology Research
Hui ChenMing Lu

Abstract

Interleukin-18 (IL-18) plays a potential pathological role in recurrent pregnancy loss (RPL). The results of published studies on the relationship between IL-18 gene promoter polymorphisms (-137G/C and-607C/A) and RPL risk remain controversial. This meta-analysis was performed to evaluate the association of IL-18, -137G/C and-607C/A gene polymorphisms with the risk of RPL under recessive, dominant and additive genetic models. A literature search was conducted in Medline, Embase and Web of Science for studies that described the effect of IL-18 gene polymorphisms on RPL risk. The numbers of each -137G/C and-607C/A genotype in the case and control groups were extracted. Quality of the original studies' methodology was also assessed. Meta-analysis was performed using Stata 13.1 software and the fixed effect model was used. Five articles were included in this meta-analysis. No significant heterogeneity between the studies was noted. The IL-18 -137 G/C polymorphism was significantly associated with an increased risk of RPL under a recessive genetic model (CC vs. GG + CG: odds ratio = 1.56, 95% confidence interval = 1.13 ~ 2.15). For the -607C/A mutation, we failed to find any association under any genetic models. The Egger's regressi...Continue Reading

References

Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Oct 12, 2000·Baillière's Best Practice & Research. Clinical Obstetrics & Gynaecology·L Regan, R Rai
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Oct 26, 2002·Human Reproduction Update·T C LiS Laird
Nov 30, 2004·Statistics in Medicine·Ammarin ThakkinstianJohn Attia
Apr 6, 2006·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Sirous NaeimiAbbas Ghaderi
Feb 17, 2007·Clinical Obstetrics and Gynecology·Joe Leigh Simpson
May 10, 2007·European Journal of Human Genetics : EJHG·Sandrine BarbauxLaurence Tiret
Oct 10, 2007·American Journal of Reproductive Immunology : AJRI·Sasa OstojićBorut Peterlin
May 20, 2008·Fertility and Sterility·UNKNOWN Practice Committee of the American Society for Reproductive Medicine
Nov 26, 2008·Fertility and Sterility·UNKNOWN Practice Committee of tAmerican Society for Reproductive Medicine
May 28, 2011·Andrologia·A KomskyD Strassburger
Mar 6, 2012·Journal of Reproductive Immunology·Safia MessaoudiTouhami Mahjoub
Aug 24, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Tayfur CiftAli Benian
Feb 23, 2013·Journal of Pregnancy·Marco BrancoAntónio Veloso
Apr 6, 2013·American Journal of Epidemiology·Sudeshna MukherjeeKatherine E Hartmann
May 2, 2014·The Journal of Investigative Dermatology·Valentina GalbiatiEmanuela Corsini
Jul 6, 2014·BioMed Research International·Daye ChengYiran Ma
Feb 15, 2015·Postgraduate Medical Journal·Carmen Garrido-Gimenez, Jaume Alijotas-Reig
Feb 19, 2015·International Journal of Molecular Sciences·Jun YueJiyun Yang
Apr 7, 2015·Research in Veterinary Science·Sonia Almería, Fernando López-Gatius

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Citations

Oct 18, 2016·BioMed Research International·Veronika GüntherChristel Eckmann-Scholz
Nov 1, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Yan GuJing Du
Jan 10, 2018·Journal of Assisted Reproduction and Genetics·Luis Alejandro Arias-SosaMaribel Forero-Castro
Dec 4, 2016·Journal of Endocrinological Investigation·A SalmassiA G Schmutzler
Apr 13, 2017·Virology Journal·Mukesh KumarVivek R Nerurkar
Nov 21, 2019·European Journal of Epidemiology·Sanne A E PetersUNKNOWN China Kadoorie Biobank Collaboration Group

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