Interleukin-18 is a strong predictor of hospitalization in haemodialysis patients

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Chih-Kang ChiangTun-Jun Tsai

Abstract

Morbidity and mortality rates are high among patients with end-stage renal disease (ESRD), and recent evidence suggests that this may be linked to inflammation. Current research has also demonstrated the crucial involvement of interleukin-18 (IL-18) in inflammation. In agreement, the activity of IL-18 has been markedly up-regulated in ESRD patients. However, it has not been established whether elevated plasma IL-18 predicts outcome in haemodialysis (HD) patients. To determine whether plasma IL-18 predicts overall hospitalization, we studied 184 ESRD patients (62% males, 58.5+/-1.0 years of age) undergoing maintenance HD treatment. The patients were followed for 12 months and were stratified by the tertiles of plasma IL-18 levels. Classic factors, such as age, body mass index, duration of HD, nutritional and inflammatory parameters, co-morbidity, dialysis adequacy, and lipid status were entered into a Cox regression model to predict hospitalization. The Kaplan-Meier method was used to analyse the cumulative proportion of hospitalization-free events. Significantly different hospitalization days and frequencies (P<0.05) were observed when patients were divided according to tertiles of plasma IL-18 levels. Patients were stratified ...Continue Reading

Citations

Jul 31, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Yen-Ling ChiuTun-Jun Tsai
Sep 9, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Tomasz PorazkoMarian Klinger
Dec 17, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Scott D CohenPaul L Kimmel
Aug 28, 2009·Seminars in Dialysis·Griet GlorieuxRaymond Vanholder
Apr 9, 2008·Kidney & Blood Pressure Research·Katarzyna Kiliś-PstrusińskaAnna Wawro
Apr 19, 2008·Blood Purification·Juan Jesus CarreroPeter Stenvinkel
May 2, 2014·Seminars in Nephrology·Michal ChmielewskiJuan Jesús Carrero
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Jul 20, 2018·International Heart Journal·Shiying WangJun Shi
Jan 24, 2019·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Alaleh GheissariMehryar Mehrkash
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Mar 15, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Sung-Soo JungKiichi Nakahira

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