Interleukin-18 promoter polymorphisms and the disease progression of Hepatitis B virus-related liver disease

Translational Research : the Journal of Laboratory and Clinical Medicine
Kiyoshi MigitaHiromi Ishibashi

Abstract

In this study, we aimed to explore whether interleukin-18 (IL-18) gene-promoter polymorphisms are associated with the outcome of hepatitis B virus (HBV) infection. In all, 204 chronically HBV-infected patients were recruited in this study. Of the 204 HBV-infected patients, 43 were considered to be inactive HBV carriers based on the sustained normalization of serum alanine aminotransferase (ALT) together with seropositivity for the antibody to hepatitis B e-antigen (anti-HBe). A total of 161 patients were found to have chronic progressive liver disease, which included cirrhosis. In these HBV-infected patients, the frequencies of AA genotype of IL-18 gene-promoter polymorphisms at position -607 and C allele at position -137 were significantly higher in inactive HBV carriers compared with those in patients with chronic progressive liver disease. These polymorphisms of the IL-18 promoter regions (-607 and -137) could be associated with different outcomes of HBV infection.

References

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Citations

May 31, 2014·World Journal of Gastroenterology : WJG·Semra Tunçbilek
Sep 13, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Pu XiaYang Bai
May 9, 2015·Journal of Medical Virology·Sandro da Costa FerreiraAna de Lourdes Candolo Martinelli
Mar 31, 2016·PLoS Neglected Tropical Diseases·Daniel A Leon RodriguezJavier Martin
Jul 13, 2019·Innate Immunity·Li-Hong Zhou, Yun-Feng Sheng
May 16, 2019·Viral Immunology·Sahar Amirpour-Rostami, Mohammad Kazemi Arababadi

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