Interleukin-1A +4845(G> T) polymorphism is a factor predisposing to acne vulgaris

Tissue Antigens
Kornélia SzabóL Kemény

Abstract

Acne vulgaris is a common chronic inflammatory skin disease of multifactorial origin. The aim of this study was to clarify whether known polymorphisms of the interleukin-1A (IL1A) and IL1RN genes play a role in the pathogenesis of acne vulgaris. A positive association was found between the minor T allele of the IL1A +4845(G>T) single nucleotide polymorphism (SNP) and acne, whereas no association was found with respect to any alleles of the variable number of tandem repeats (VNTR) polymorphism of the IL1RN gene. The severity of inflammatory acne symptoms correlated with the percentage of individuals carrying the homozygote T/T genotype. These results may help to elucidate the molecular events leading to the development of acne.

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Citations

Jan 9, 2014·Nature Communications·Li HeYa-Ping Zhang
Oct 12, 2013·Human Genetics·Mingfeng ZhangJiali Han
Jun 15, 2011·Human Immunology·Kornélia Szabó, Lajos Kemény
Jan 4, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·M SobjanekJ Roszkiewicz
Mar 5, 2013·Journal of the American Academy of Dermatology·Tien V NguyenKieron S Leslie
Apr 11, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·J P ClaudelB Dréno
Jun 9, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·R LichtenbergerA A Navarini
Mar 3, 2018·Journal of Cosmetic Dermatology·Adel A IbrahimShimaa Hussein
Mar 12, 2019·The British Journal of Dermatology·J E A CommonM A M van Steensel

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