PMID: 11911995Mar 26, 2002Paper

Interleukin-1A polymorphism is not associated with late onset Alzheimer's disease

Neuroscience Letters
Liana FidaniJohn Hardy

Abstract

Over the past few years, association studies have proposed a number of potential genetic risk factors for Alzheimer's disease (AD). With the exception of the varepsilon4 allele of the apolipoprotein E gene, whose association with the late onset type of AD (LOAD) has been confirmed, the relative significance of most of these associations is still in question. A polymorphism in the interleukin-1A gene (IL-1A2) has been suggested as a risk factor for the early onset as well as for LOAD. In this study, the distribution of IL-1A alleles was examined in a cohort of predominantly LOAD patients and in control individuals. No significant difference was detected in genotype or allele frequencies (odds ratios of 0.929 and 0.743, respectively; P>0.5). We conclude that IL-1A genotype is not a major risk factor for LOAD.

References

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Citations

Mar 15, 2005·Journal of Neuroinflammation·Nikunj S PatelMichael J Mullan
Oct 12, 2004·The International Journal of Biochemistry & Cell Biology·Ehab E Tuppo, Hugo R Arias
Oct 3, 2006·Expert Review of Neurotherapeutics·Martina ChiappelliFederico Licastro
Jun 5, 2003·Psychiatric Genetics·Jordi ClarimónDavid Comas
Jul 12, 2007·Dementia and Geriatric Cognitive Disorders·Hsiu-Kuan WangChiung-Mei Chen

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