Abstract
Over the past few years, association studies have proposed a number of potential genetic risk factors for Alzheimer's disease (AD). With the exception of the varepsilon4 allele of the apolipoprotein E gene, whose association with the late onset type of AD (LOAD) has been confirmed, the relative significance of most of these associations is still in question. A polymorphism in the interleukin-1A gene (IL-1A2) has been suggested as a risk factor for the early onset as well as for LOAD. In this study, the distribution of IL-1A alleles was examined in a cohort of predominantly LOAD patients and in control individuals. No significant difference was detected in genotype or allele frequencies (odds ratios of 0.929 and 0.743, respectively; P>0.5). We conclude that IL-1A genotype is not a major risk factor for LOAD.
References
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·W S GriffinC Araoz
Jul 1, 1984·Neurology·G McKhannE M Stadlan
Aug 1, 1994·Journal of Neuroscience Methods·R CrookK Duff
Feb 1, 1995·Arthritis and Rheumatism·T L McDowellG W Duff
Feb 1, 1994·Neurology·J C BreitnerJ C Anthony
Feb 5, 1999·Human Molecular Genetics·P KehoeM J Owen
Mar 15, 2000·Annals of Neurology·L M GrimaldiM Franceschi
Mar 15, 2000·Annals of Neurology·J A NicollW S Griffin
Aug 23, 2000·Neurology·Y DuM R Farlow
Nov 7, 2000·Neuroscience Letters·G W Rebeck
Citations
Jan 12, 2012·Journal of Neurology·Xue QinJinmin Zhao
Jan 17, 2013·Journal of Neural Transmission·Bing-Hu LiJing-Cheng Li
Sep 17, 2002·Neuroscience Letters·Antonis GoulasJohn Hardy
May 22, 2003·Neuroscience Letters·Shih-Jen TsaiChen-Jee Hong
Mar 15, 2005·Journal of Neuroinflammation·Nikunj S PatelMichael J Mullan
Jan 16, 2016·Molecular Neurobiology·Xiaoliu DongQiuyan Gao
Oct 12, 2004·The International Journal of Biochemistry & Cell Biology·Ehab E Tuppo, Hugo R Arias
Oct 3, 2006·Expert Review of Neurotherapeutics·Martina ChiappelliFederico Licastro
Apr 20, 2012·Journal of Neuroscience Research·Ye HuaXiaojie Lu
Oct 18, 2019·Medicina·Greta PšemeneckienėAnd Daiva Rastenytė
Jun 5, 2003·Psychiatric Genetics·Jordi ClarimónDavid Comas
Jul 12, 2007·Dementia and Geriatric Cognitive Disorders·Hsiu-Kuan WangChiung-Mei Chen
Jul 28, 2019·Acta Neuropathologica Communications·Suman DeDavid Klenerman
May 12, 2020·Journal of Alzheimer's Disease : JAD·Mirjana Babić LekoGoran Šimić