Interleukin-1alpha in the brain is induced by audiogenic seizure

Neurobiology of Disease
L C GahringS W Rogers

Abstract

We examined the expression of the sleep-inducing cytokine interleukin-1alpha (IL-1alpha) in the brains of audiogenic seizure-susceptible mice subsequent to the induction of sound-induced seizure. Animal models of epilepsy often require lesioning or trauma that may nonspecifically alter IL-1alpha expression. To avoid this, we employed the Frings mouse strain; a model of auditory-evoked reflex epilepsy. Frings mice were exposed to a high-intensity sound stimulus to induce a tonic extension seizure, and the expression of IL-1alpha transcripts in different brain regions was measured thereafter. Compared to control animals, IL-1alpha transcripts were elevated 6 to 8 h postseizure in the hypothalamus, but not hippocampus, by a dexamethasone-sensitive pathway. Similar results were obtained from the genetically distinct DBA/2J audiogenic seizure-susceptible mouse strain. These findings demonstrate that the expression of IL-1alpha is altered following generalized seizure activity, induced by noninvasive sensory stimulation, in a brain-region-specific manner.

Citations

Aug 18, 2000·The European Journal of Neuroscience·M G De SimoniA Vezzani
Nov 24, 2005·Epilepsia·Annamaria Vezzani, Tiziana Granata
Aug 5, 2006·Epilepsia·Teresa RavizzaAnnamaria Vezzani
Nov 5, 1999·Alcoholism, Clinical and Experimental Research·L C GahringS W Rogers
May 17, 2007·Epilepsy Currents·Annamaria Vezzani, Tallie Z Baram
Aug 2, 2005·Epilepsy Currents·Annamaria Vezzani
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·S M AllanN J Rothwell
Feb 11, 2005·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·An D BilliauLieven G Lagae
Oct 5, 2010·Pharmacological Reports : PR·Radosław ZarczukKinga K Borowicz
Mar 13, 2008·Journal of Neuroscience Research·Aiden HaghikiaPedro M Faustmann
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Dec 29, 2000·Molecular Psychiatry·L VitkovicC Jacque
Jan 8, 2009·Physiological Reviews·Edson X AlbuquerqueScott W Rogers
Jul 19, 2005·Journal of Neuroimmunology·Lorise C GahringScott W Rogers

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