PMID: 9654172Jul 8, 1998Paper

Interleukin-1alpha, interleukin-6 and interleukin-8 in cervico/vaginal secretion for screening of preterm birth in twin gestation

Acta Obstetricia Et Gynecologica Scandinavica
U B WennerholmHenrik Hagberg

Abstract

The purpose was to determine the prognostic value of interleukin (IL) 1-alpha, IL-6 and IL-8 in cervico/vaginal secretion for preterm birth (<37 weeks of gestation) in twin pregnancies. The study included screening of 121 women with twin pregnancies with sampling at 24, 26, 28, 30, 32 and 34 weeks of gestation. IL-1alpha, IL-6 and IL-8 was analyzed with ELISA immunoassays. The detection limit was 30 pg/mL for IL-1 and IL-8 and 40 pg/mL for IL-6. Vaginal fluid was smeared and dried for later evaluation of bacterial vaginosis (presence of clue cells). Spontaneous preterm birth occurred in 36 women and 65 women were delivered at term. IL-8 was significantly higher (p=0.03) in samples from women delivered preterm (median 3.72 ng/g mucus, range <0.07-220.00) compared with samples from women delivered at term (median 3.03 ng/g mucus, range <0.08-378.60). At 28 weeks of gestation, IL-8 (cut off 1.75 ng/g mucus) was associated with preterm delivery (relative risk 2.2, CI 95% 1.1-4.5) with a sensitivity, specificity, positive and negative predictive value of 78.8, 45.8, 44.8 and 79.4%, respectively. The levels of IL-1alpha and IL-6 were not significantly associated with preterm birth. Bacterial vaginosis was found in 47/541 (8.7%) sampl...Continue Reading

Citations

Mar 7, 2007·Current HIV/AIDS Reports·Elizabeth St JohnGregory T Spear
Feb 23, 2005·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·U ForsumI Mattsby-Baltzer
Apr 10, 2008·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Natalia NikolaitchoukInger Mattsby-Baltzer
Mar 21, 2007·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Louise StrömbeckInger Mattsby-Baltzer
Mar 18, 2011·American Journal of Reproductive Immunology : AJRI·Joon-Cheol ParkJoanne Kwak-Kim
Jul 25, 2014·The Journal of Obstetrics and Gynaecology Research·Embiye YilmazGuven Ozkaya
Jul 30, 2014·American Journal of Obstetrics and Gynecology·Agustin Conde-Agudelo, Roberto Romero
Jan 24, 2007·American Journal of Obstetrics and Gynecology·Hyagriv N SimhanSharon L Hillier
Jan 4, 2006·American Journal of Obstetrics and Gynecology·Roberto RomeroSonia Hassan
Jul 11, 2008·Infectious Diseases in Obstetrics and Gynecology·Kathy J AgnewJane Hitti

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