Interleukin-1B and interleukin-1 receptor antagonist gene polymorphisms are not associated with premalignant gastric conditions: a combined haplotype analysis

European Journal of Gastroenterology & Hepatology
Limas KupcinskasPeter Malfertheiner

Abstract

Contradictory results have been reported about the role of interleukin-1B (IL1B) and IL1 receptor antagonist (IL1RN) alleles in gastric carcinogenesis. Here, IL1B and IL1RN polymorphisms were analyzed as genotypes and haplotypes in relation to the presence of atrophic gastritis (AG) and intestinal metaplasia in the stomach. Two hundred and seventy-eight patients (212 Caucasians and 66 Asians) aged 50 years and above, referred for upper endoscopy because of dyspeptic symptoms, were included in the study. Gastric biopsies were histologically assessed according to the updated Sydney classification. Genomic DNA was typed for polymorphisms at position -3737, -1464, -511, -31 for the IL1B gene and the allele 2 of IL1RN using restriction fragment length polymorphism of amplified PCR fragments and intron-spanning PCR analysis, respectively. IL1B-1464-C/C genotype was associated with higher presence of AG in antrum of the stomach in Caucasians [odds ratio: 4.8 (95% confidence interval=1.7-14.3); P=0.028]. IL1B-1464-G/C genotype was associated with lower incidence of AG in corpus of the stomach in Asians [odds ratio: 0.7 (95% confidence interval=0.5-0.8); P=0.02]. IL1RN*2 allele was not linked with AG or intestinal metaplasia in all part...Continue Reading

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Citations

May 2, 2014·World Journal of Gastroenterology : WJG·Juwon KimKyung-A Lee
Jun 23, 2012·Digestive Diseases·Marcis LejaPeter Malfertheiner
Aug 11, 2018·Environmental and Molecular Mutagenesis·Zareen SultanaMadhusudan Das
Mar 10, 2012·Journal of the Korean Surgical Society·Seok Youn LeeSoo Cheon Chae
Jun 10, 2017·World Journal of Gastroenterology : WJG·Vytenis PetkeviciusJuozas Kupcinskas
Jul 28, 2020·Gastroenterology Research and Practice·Mindaugas UrbaJuozas Kupcinskas
Jun 3, 2021·International Journal of Molecular Sciences·Paulius JonaitisJuozas Kupcinskas
Sep 11, 2021·Cellular and Molecular Gastroenterology and Hepatology·Annemieke SmetJan Bornschein

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Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.