PMID: 9552129Apr 29, 1998Paper

Interleukin-1beta and its type 1 receptor are expressed in developing neural circuits in the frog, Xenopus laevis

The Journal of Comparative Neurology
A M JelasoC F Ide

Abstract

The cytokine interleukin-1 beta (IL-1beta) is an evolutionarily conserved molecule that was originally identified in the immune system. In addition to regulating peripheral immune responses, IL-1beta plays an important role in mediating neural-immune interactions and regulating glial activities during healing and repair in the damaged nervous system. Active IL-1beta is produced by interleukin-converting enzyme (ICE), a caspase thought to be involved in the induction of apoptosis. We report that, in the developing frog, Xenopus laevis, IL-1beta and the IL-1 type 1 receptor proteins are coexpressed in specific neurons that comprise early sensory-motor circuits. IL-1beta and IL-1 type 1 receptor proteins are colocalized in specific midbrain and hindbrain reticular cells, including Mauthner's neuron; specific cells in the trigeminal (fifth), lateral line (seventh), and vestibular (eighth) cranial ganglia; oculomotor neurons; and the primordial Purkinje cells of the lateral cerebellar auricle. In the spinal cord, Rohon-Beard sensory neurons, dorsal root ganglion cells, and primary motoneurons are immunopositive. Anteriorly, the olfactory pits, olfactory nerves, and olfactory bulbs are labeled, as are retinal cells, especially photor...Continue Reading

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Citations

Sep 5, 2002·Environmental and Molecular Mutagenesis·Anna M JelasoCharles F Ide
Jul 23, 2003·Environmental and Molecular Mutagenesis·Anna M JelasoCharles F Ide
Dec 11, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·I PitaC F Ide
Sep 7, 2005·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Anna M Jelaso, Cari DeLong
Apr 17, 2019·Seminars in Immunopathology·Marianne Böni-Schnetzler, Daniel T Meier

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