PMID: 11328198May 1, 2001Paper

Interleukin-1beta converting enzyme/Caspase-1 (ICE/Caspase-1) and soluble APO-1/Fas/CD 95 receptor in amyotrophic lateral sclerosis patients

Acta Neurologica Scandinavica
J IłzeckaB Dobosz

Abstract

The aim of the study was to investigate the role of ICE/ Caspase-1 and soluble APO-1/Fas/CD 95 receptor in amyotrophic lateral sclerosis patients. The apoptosis parameters were measured by enzyme-linked immunosorbent assay (ELISA) in serum and cerebrospinal fluid from 25 amyotrophic lateral sclerosis and 15 control patients. There has been shown a significant increase of ICE/Caspase-1 level in serum, and significant decrease of this parameter in cerebrospinal fluid from amyotrophic lateral sclerosis patients. Soluble APO-1/Fas/CD 95 level in amyotrophic lateral sclerosis patients did not differ from the control group. There was no significant correlation between clinical status, duration of amyotrophic lateral sclerosis, and levels of ICE/Caspase-1 and soluble APO-1/Fas/CD 95. Our study suggests that ICE/Caspase-1 may play a role in neurodegeneration in ALS. Due to ethical difficulties we cannot include patients suffering from progressive neurological diseases, who are a more appropriate control group for the amyotrophic lateral sclerosis patients. Therefore we are limited in drawing conclusions from the research.

Citations

Jan 24, 2004·Brain Research. Brain Research Reviews·Chulhee Choi, Etty N Benveniste
Jun 5, 2003·Pharmacology & Therapeutics·Michael J Strong
Feb 25, 2003·The American Journal of Pathology·Srikanth Ranganathan, Robert Bowser
Nov 7, 2012·Proteomics. Clinical Applications·Thomas KrügerHeidrun Rhode
Aug 22, 2006·Biochimica Et Biophysica Acta·Xin WangRobert M Friedlander

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