Interleukin-1beta gene polymorphism associated with hepatocellular carcinoma in hepatitis B virus infection

World Journal of Gastroenterology : WJG
Nattiya HirankarnYong Poovorawan

Abstract

To examine the effect of interleukin-1-beta (IL-1beta) promoter region C-511T and IL-1 receptor antagonist (IL-1RN) polymorphism among the patients with chronic hepatitis B virus (HBV) infection (HCC and non-HCC). Genomic DNA from 136 Thai patients with chronic HBV infection (HCC=46 and non-HCC=90) and 152 healthy individuals was genotyped for IL-1beta gene polymorphism (-511) using polymerase chain reaction with sequence specific primers (PCR-SSP). The variable number of tandem repeats (VNTR) of IL-1RN gene was assessed by a PCR-based assay. The association between these genes and status of the disease was evaluated by chi2 test. IL-1B-511 genotype C/C was found to be significantly different in patients with HCC when compared with healthy individuals (P=0.036, OR=2.29, 95%CI=1.05-4.97) and patients without HCC (P=0.036, OR=2.52, 95%CI=1.05-6.04). Analysis of allele frequencies of IL-1B-511 showed that IL-1B-511 C allele was also significantly increased in patients with HCC, compared to that in healthy control (P=0.033, OR=1.72, 95%CI=1.04-2.84). However, no significant association in IL-1RN gene was found between the two groups. IL-1B-511C allele, which may be associated with high IL-1B production in the liver, is a genetic ma...Continue Reading

References

Jan 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J van HattumS W Schalm
Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Oct 1, 1994·Journal of Medical Virology·F E André, A J Zuckerman
Oct 29, 1994·Lancet·A Almarri, J R Batchelor
Dec 11, 1997·The New England Journal of Medicine·W M Lee
Mar 31, 1998·Scandinavian Journal of Immunology·S SanttilaM Hurme
May 29, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S H AhnY M Moon
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·Z TianB Gao
May 11, 2001·Japanese Journal of Cancer Research : Gann·N HamajimaS Tominaga
Jan 16, 2002·American Journal of Respiratory and Critical Care Medicine·Beata HutyrováMartin Petrek
Feb 5, 2002·Current Gastroenterology Reports·Robert P Perrillo
Nov 21, 2002·Journal of the National Cancer Institute·Céu FigueiredoManuel Sobrinho-Simões
Dec 25, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yue WangMasao Omata
Jan 16, 2003·The American Journal of Gastroenterology·Ziv Ben-AriTirza Klein
Jan 28, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M BortolamiF Farinati
Aug 2, 2003·Gastroenterology·José Carlos MachadoManuel Sobrinho-Simões
Aug 14, 2003·Human Molecular Genetics·Yoon Jun KimHyoung Doo Shin
Jun 4, 2004·Journal of Gastroenterology·Kyung-A LeeTae Sung Sohn
Jun 10, 2004·World Journal of Gastroenterology : WJG·Ping-An ZhangJian-Min Wu
Nov 20, 2004·International Journal of Cancer. Journal International Du Cancer·Young-Woon ChangRin Chang

❮ Previous
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Citations

Oct 6, 2007·Current Opinion in Rheumatology·Esther van de Vosse, Michiel A van Agtmael
Oct 23, 2015·International Journal of Endocrinology·Maurizio MontellaAldo Giudice
May 27, 2017·Science China. Life Sciences·Bo ZhengLei Chen
Dec 25, 2007·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Ranbir Chander SobtiVanita Suri
Dec 6, 2012·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Roli SaxenaJyotdeep Kaur
Sep 2, 2006·Journal of Leukocyte Biology·Anuradha Budhu, Xin Wei Wang
Nov 12, 2009·Journal of Cancer Research and Clinical Oncology·Nianfeng QianZhibin Hu
Mar 18, 2011·Tissue Antigens·P SodsaiN Hirankarn
Nov 26, 2010·Journal of Cancer Research and Clinical Oncology·Yu YangSheng Bi
Aug 30, 2016·World Journal of Gastroenterology : WJG·Mahmoud Fathy DondetiRoba Mohamed Talaat
Dec 17, 2017·Immunological Reviews·Khaled KhazimIdan Cohen
Sep 25, 2017·Biochemistry. Biokhimii︠a︡·M V NovikovaP B Kopnin
May 16, 2019·Viral Immunology·Sahar Amirpour-Rostami, Mohammad Kazemi Arababadi
Feb 4, 2012·Cancer Immunology, Immunotherapy : CII·Keisuke KohgaTetsuo Takehara
Jul 26, 2008·PLoS Computational Biology·Wannipha TongsimaPrasit Palittapongarnpim
Apr 10, 2013·International Journal of Immunogenetics·I KimkongN Hirankarn
Aug 30, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Chun-Hua BeiXiao-Qiang Qiu
Mar 17, 2010·Oncogene·W-L Tsai, R T Chung
Jul 14, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Runqiu JiangBeicheng Sun
Nov 17, 2020·SAGE Open Medicine·Mohammad Nurul AminFarhana Sultana
Apr 4, 2021·International Journal of Molecular Sciences·Wasitha P D Wass ThilakarathnaNeale D Ridgway
Nov 28, 2006·Journal of Hepatology·Kiyoshi MigitaHiromi Ishibashi

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