Interleukin-1beta in antigen-induced arthritis of the rabbit temporomandibular joint

Archives of Oral Biology
K TominagaS Kopp

Abstract

The aim was to investigate joint perfusate levels of interleukin-1beta (IL-1beta) in antigen-induced monoarthritis of the rabbit temporomandibular (TMJ) and knee joints. Twenty-four adult male New Zealand White rabbits were divided into three groups: a control group as well as TMJ arthritis and knee joint arthritis groups. After sensitization, unilateral arthritis was induced by intra-articular injection with ovalbumin and the contralateral joint was injected with saline 3 weeks after induction of arthritis. Joints were then perfused continuously with saline and samples were collected at 10-min intervals over a 50-min period. The IL-1beta concentrations in the samples were then analyzed. After killing the animals, the joints were examined histologically. The IL-1beta concentrations in the samples from the arthritic TMJs and knee joints were significantly higher than in the saline-injected and the control joints. Histological signs of chronic arthritis of similar severity were found in both joints. The IL-1beta levels in the samples from the arthritic TM and knee joints correlated with the histological severity of the arthritis, including pannus formation. In conclusion, this study shows that IL-1beta is released in the synovium...Continue Reading

References

Mar 1, 1990·Arthritis and Rheumatism·W P Arend, J M Dayer
May 1, 1994·Current Opinion in Rheumatology
Sep 12, 1998·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·P AlstergrenS Kopp
Jul 22, 1999·Archives of Oral Biology·K TominagaS Kopp

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Citations

Mar 19, 2002·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Manabu HabuJinichi Fukuda
Dec 2, 2015·Experimental and Therapeutic Medicine·Wei-Wei LiuBing Han
Jan 25, 2006·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Yuriko HirotaJinichi Fukuda
Sep 6, 2005·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·K FujimuraN Segami
Oct 19, 2011·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Taishi OhtaniKazuhiro Tominaga

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