Abstract
Sickness behaviors are a set of adaptive responses to infection that include lethargy, anorexia, and, of direct relevance to this work, learning and memory impairments. The proinflammatory cytokine, interleukin-1 beta (IL-1beta) has been proposed as the primary peripheral mediator of these sickness behaviors, though few studies have investigated the effects of peripheral IL-1beta on learning and memory. We used three different versions of the Morris water task (Morris water task), a spatial learning and memory task, to separately assess the effects of peripheral IL-1beta on acquisition, consolidation, and retention of spatial location information. Using a dose that induced anorexia, assessed as a significant reduction in body weight, we observed no performance impairments in the IL-1beta-treated rats across the different versions of the task, suggesting that peripheral IL-1beta alone is insufficient to induce spatial learning and memory impairments in the rat. The observed dissociation of anorexia and cognitive dysfunction suggests that, either spatial learning and memory are not principal components of the sickness response, or cognitive dysfunction requires different or additional peripheral mediator(s).
References
Feb 28, 1992·Brain Research·R M BluthéK W Kelley
Aug 14, 1992·Brain Research·F DelluH Simon
Aug 28, 1991·Journal of Immunological Methods·S Poole, R E Gaines Das
Jan 1, 1988·Neuroscience and Biobehavioral Reviews·B L Hart
Jun 1, 1995·Brain, Behavior, and Immunity·M GibertiniT W Klein
Oct 1, 1995·Proceedings of the Society for Experimental Biology and Medicine·M GibertiniH Friedman
Jun 4, 1993·Brain Research·M S OitzlE R de Kloet
Sep 1, 1996·Brain, Behavior, and Immunity·R YirmiyaA N Taylor
Jun 18, 1998·Annals of the New York Academy of Sciences·R DantzerK W Kelley
Sep 8, 1998·Neuroimmunomodulation·M Gibertini
Oct 13, 1999·Brain Research·L AloeM Fiore
Nov 30, 2000·Neuroreport·K M FrickJ Berger-Sweeney
Feb 24, 2001·Autonomic Neuroscience : Basic & Clinical·G N LuheshiR Dantzer
Mar 22, 2001·Brain, Behavior, and Immunity·R Dantzer
Aug 23, 2002·Behavioural Brain Research·Ruth M BarrientosSteven F Maier
Nov 15, 2002·Neurobiology of Learning and Memory·R YirmiyaI Goshen
Mar 5, 2003·Brain, Behavior, and Immunity·Steven F Maier, Linda R Watkins
Apr 5, 2003·Brain, Behavior, and Immunity·Steven F Maier
Aug 23, 2003·Neurobiology of Learning and Memory·Francis X BrennanRichard J Servatius
Nov 19, 2003·Hippocampus·Avi AvitalRaz Yirmiya
Dec 5, 2003·Cerebral Cortex·H GolanM Huleihel
Dec 31, 2003·Molecular Psychiatry·C SongD F Horrobin
Jun 23, 2004·Neurobiology of Disease·Joachim GerberRoland Nau
Jul 22, 2004·Brain, Behavior, and Immunity·V Hugh Perry
Sep 6, 2005·Brain Research Bulletin·Lisa M Thomson, Robert J Sutherland
Citations
Oct 1, 2010·Neuroscience Bulletin·Zhen-Bo HuangGuo-Qing Sheng
Nov 30, 2010·Neuroscience Bulletin·Zhen-Bo Huang, Guo-Qing Sheng
Dec 13, 2007·Neuroimmunomodulation·Gustavo Pacheco-LópezManfred Schedlowski
Jun 4, 2011·Brain, Behavior, and Immunity·Tanya SwanepoelDuncan Mitchell
Dec 9, 2008·Neuroscience Letters·Melissa Y T ChanKlaus-Peter Ossenkopp
Jul 22, 2008·Brain, Behavior, and Immunity·Colm Cunningham, David J Sanderson
Jul 23, 2011·Neuroscience and Biobehavioral Reviews·Paul J KennedyJohn F Cryan
May 18, 2010·Neurobiology of Aging·Carol MurrayColm Cunningham
Oct 7, 2008·Brain, Behavior, and Immunity·Shelley K Cross-MellorKlaus-Peter Ossenkopp
Dec 3, 2014·Brain, Behavior, and Immunity·Jennifer CzerniawskiJohn F Guzowski
May 18, 2016·Physiology & Behavior·Tanya SwanepoelLois M Harden
Aug 28, 2016·Pharmacology, Biochemistry, and Behavior·Caylen J CloutierKlaus-Peter Ossenkopp
Dec 11, 2008·Metabolic Brain Disease·Aye Mu MyintBrian E Leonard