Interleukin-1beta modulates state-dependent discharge activity of preoptic area and basal forebrain neurons: role in sleep regulation

The European Journal of Neuroscience
Md Noor AlamR Szymusiak

Abstract

Interleukin-1beta (IL-1) is a pro-inflammatory cytokine that has been implicated in the regulation of nonrapid eye movement (nonREM) sleep. IL-1, IL-1 receptors and the IL-1 receptor antagonist (ra) are present normally in discrete brain regions, including the preoptic area (POA) of the hypothalamus and the adjoining magnocellular basal forebrain (BF). The POA/BF have been implicated in the regulation of sleep-wakefulness. We hypothesized that IL-1 promotes nonREM sleep, in part by altering the state-dependent discharge activity of POA/BF neurons. We recorded the sleep-wake discharge profiles of 83 neurons in the lateral POA/BF and assessed the effects of IL-1, IL-1ra, and IL-ra + IL-1 delivered through a microdialysis probe on state-dependent neuronal discharge activity. IL-1 decreased the discharge rate of POA/BF neurons as a group (n = 55) but wake-related and sleep-related neurons responded differently. IL-1 significantly decreased the discharge rate of wake-related neurons. Of 24 wake-related neurons studied, 19 (79%) neurons exhibited a greater than 20% change in their discharge in the presence of IL-1 during waking. IL-1 suppressed the discharge activity of 18 of 19 responsive neurons. Of 13 sleep-related neurons studied...Continue Reading

References

Sep 1, 1990·The American Journal of Physiology·S F Pearce, J A Zadunaisky
Jul 1, 1989·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·L A Toth, J M Krueger
Oct 1, 1988·The International Journal of Neuroscience·F A LueH Moldofsky
Jul 1, 1988·Infection and Immunity·L A Toth, J M Krueger
Nov 1, 1994·Brain Research. Molecular Brain Research·K YabuuchiM Satoh
Jan 12, 1996·Science·J E SherinC B Saper
Dec 1, 1996·The American Journal of Physiology·A TakahashiR A Frizzell
May 30, 1998·Journal of Neuroscience Methods·T SaitoT Nemoto
Jun 20, 1998·Progress in Brain Research·T Hori, T Katafuchi
Oct 13, 1998·The Journal of Allergy and Clinical Immunology·L J Rosenwasser
Jan 4, 2001·Trends in Neurosciences·N J Rothwell, G N Luheshi
Nov 24, 2001·Trends in Neurosciences·C B SaperT E Scammell
Feb 20, 2002·Trends in Neurosciences·Jan Pieter KonsmanRobert Dantzer
Jan 18, 2003·Sleep Medicine Reviews·Tarja Porkka-HeiskanenDag Stenberg
Apr 18, 2003·Frontiers in Bioscience : a Journal and Virtual Library·Ferenc Obal, James M Krueger
Sep 6, 2003·Frontiers in Bioscience : a Journal and Virtual Library·Dennis McGinty, Ronald Szymusiak

❮ Previous
Next ❯

Citations

Mar 25, 2010·Journal of Neurology·Anna O G Goodman, Roger A Barker
Nov 6, 2008·Nature Reviews. Neuroscience·James M KruegerJaak Panksepp
Feb 12, 2009·Nature Reviews. Neuroscience·Luca Imeri, Mark R Opp
Oct 12, 2005·Current Opinion in Pulmonary Medicine·Fotis KapsimalisMeir Kryger
Feb 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Christopher N DavisTamas Bartfai
Nov 18, 2014·Journal of Medicinal Food·Leo Galland
Jun 5, 2013·The Journal of Nutrition, Health & Aging·M GarridoA B Rodríguez
Sep 1, 2012·Sleep Medicine Clinics·Christopher J Davis, James M Krueger
May 26, 2007·Brain, Behavior, and Immunity·Danielle J FreyKenneth P Wright
Sep 17, 2013·International Forum of Allergy & Rhinology·Jeremiah A Alt, Timothy L Smith
Oct 31, 2013·International Journal of Radiation Biology·Paola Ballesteros-ZebaduaCarlos Paz
Jan 4, 2012·Sleep Medicine·Elio LugaresiPietro Cortelli
May 17, 2005·Sleep Medicine Reviews·Eric A Nofzinger
Dec 18, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·F C BakerD McGinty
Nov 25, 2005·Anesthesiology·Ralph Lydic, Helen A Baghdoyan
Nov 12, 2005·Journal of Neurophysiology·Yuichi TamakawaMitsuyuki Nakao
Feb 4, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Luca ImeriMark R Opp
Jun 25, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·George F Koob, Ian M Colrain
Jun 9, 2019·International Journal of Molecular Sciences·William H Walker, Jeremy C Borniger
May 9, 2013·The European Journal of Neuroscience·James M KruegerDaniel J Buysse
Nov 1, 2013·Journal of Neurophysiology·Md Aftab AlamRonald Szymusiak
Jul 12, 2019·Journal of Applied Physiology·Joseph NguyenJames M Krueger
Aug 12, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michael R Irwin, Mark R Opp
Nov 24, 2016·BMC Neuroscience·Tzu-Rung HuangFang-Chia Chang
Aug 15, 2020·Frontiers in Neurology·Cenglin XuZhong Chen
Aug 1, 2006·Neurologic Clinics·Mark R Opp
Apr 25, 2009·Immunology and Allergy Clinics of North America·Mark R Opp

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

Basal Forebrain & Food Avoidance

Neurons in the basal forebrain play specific roles in regulating feeding. Here are the latest discoveries pertaining to the basal forebrain and food avoidance.