Interleukin-1beta selectively expands and sustains interleukin-22+ immature human natural killer cells in secondary lymphoid tissue.

Immunity
Tiffany HughesMichael A Caligiuri

Abstract

Among human natural killer (NK) cell intermediates in secondary lymphoid tissue (SLT), stage 3 CD34(-)CD117(+)CD161(+)CD94(-) immature NK (iNK) cells uniquely express aryl hydrocarbon receptor (AHR) and interleukin-22 (IL-22), supporting a role in mucosal immunity. The mechanisms controlling proliferation and differentiation of these cells are unknown. Here we demonstrate that the IL-1 receptor IL-1R1 was selectively expressed by a subpopulation of iNK cells that localized proximal to IL-1beta-producing conventional dendritic cells (cDCs) within SLT. IL-1R1(hi) iNK cells required continuous exposure to IL-1beta to retain AHR and IL-22 expression, and they proliferate in direct response to cDC-derived IL-15 and IL-1beta. In the absence of IL-1beta, a substantially greater fraction of IL-1R1(hi) iNK cells differentiated to stage 4 NK cells and acquired the ability to kill and secrete IFN-gamma. Thus, cDC-derived IL-1beta preserves and expands IL-1R1(hi)IL-22(+)AHR(+) iNK cells, potentially influencing human mucosal innate immunity during infection.

References

Apr 1, 1996·The Journal of Experimental Medicine·A KratzN H Ruddle
Jul 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·K MakiK Ikuta
Oct 29, 2003·Journal of Immunological Methods·Michael R BettsRichard A Koup
Aug 17, 2004·Immunity·Kerstin WolkRobert Sabat
Dec 18, 2004·Journal of Immunological Methods·Galit AlterMarcus Altfeld
Apr 12, 2006·The Journal of Experimental Medicine·Aharon G FreudMichael A Caligiuri
Nov 15, 2006·Immunological Reviews·Aharon G Freud, Michael A Caligiuri
Aug 7, 2007·Nature Immunology·Nicholas J WilsonRene de Waal Malefyt
Oct 1, 2008·Nature Reviews. Immunology·Tobias JuntBurkhard Ludewig
Dec 24, 2008·The Journal of Experimental Medicine·Nicholas D HuntingtonJames P Di Santo
Mar 11, 2009·The Journal of Experimental Medicine·Melanie A KleinschekRobert A Kastelein
Jul 29, 2009·European Journal of Immunology·Joseph C Sun, Lewis L Lanier
Feb 10, 2010·The Journal of Experimental Medicine·Naoko Satoh-TakayamaJames P Di Santo

❮ Previous
Next ❯

Citations

Feb 24, 2012·Inflammatory Bowel Diseases·Atsushi Mizoguchi
Aug 22, 2013·Seminars in Immunopathology·Celine A Beamer, David M Shepherd
Sep 24, 2013·Trends in Immunology·Jianhua YuMichael A Caligiuri
Jan 23, 2013·Immunology and Cell Biology·Naomi H Philip, David Artis
Jan 8, 2013·Nature Reviews. Immunology·Jennifer A WalkerAndrew N J McKenzie
Jan 21, 2011·Proceedings of the National Academy of Sciences of the United States of America·Paola VaccaMaria Cristina Mingari
Jul 10, 2013·Proceedings of the National Academy of Sciences of the United States of America·June Ho ShinJohn B Sunwoo
Oct 9, 2013·Current Opinion in Gastroenterology·Anja Fuchs, Marco Colonna
Jan 8, 2011·Science·Eric VivierSophie Ugolini
Mar 2, 2012·The Journal of Clinical Investigation·Susan McCloryMichael A Caligiuri
Feb 5, 2011·Blood·Pierluigi Porcu, Michael Caligiuri
Apr 14, 2011·Journal of Leukocyte Biology·Jeremy P McAleer, Jay K Kolls
Nov 28, 2013·Seminars in Immunology·Leo A B JoostenCharles A Dinarello
Feb 25, 2014·Seminars in Immunology·Elisa MontaldoMaria Cristina Mingari
Mar 7, 2014·Seminars in Immunology·Frank CichockiYenan T Bryceson
Mar 26, 2014·Seminars in Immunology·Aharon G FreudMichael A Caligiuri
Aug 20, 2014·Proceedings of the National Academy of Sciences of the United States of America·Nicole von BurgDaniela Finke
Jan 10, 2012·Annual Review of Immunology·Hergen Spits, Tom Cupedo
Aug 24, 2011·Cellular and Molecular Life Sciences : CMLS·Franck BihlVeronique M Braud
Jan 1, 2013·Cellular and Molecular Life Sciences : CMLS·Mohammad SalemOle Haagen Nielsen
Mar 9, 2012·Expert Review of Anti-infective Therapy·Robert J Snelgrove
Jan 23, 2016·Frontiers in Cell and Developmental Biology·Olivia B ParksMisty Good
Dec 29, 2015·Current Opinion in Immunology·Kerstin Juelke, Chiara Romagnani
Oct 16, 2015·Cellular and Molecular Life Sciences : CMLS·John W Bostick, Liang Zhou
Jul 29, 2011·The Journal of Allergy and Clinical Immunology·Kentaro TakahashiHiroshi Nakajima
Oct 12, 2010·Current Opinion in Immunology·Marc Veldhoen, João H Duarte
Oct 17, 2015·Immunology Letters·C P PetersH Spits
Oct 3, 2015·Cellular Immunology·Reza YazdaniMazdak Ganjalikhani-Hakemi
Jun 3, 2015·European Journal of Immunology·Elisa MontaldoChiara Romagnani
Sep 23, 2014·Immunity·Andreas DiefenbachShigeo Koyasu
Mar 28, 2013·British Journal of Pharmacology·Heiko MühlJosef Pfeilschifter
Mar 16, 2013·Immunology·Niklas K BjörkströmJenny Mjösberg
Feb 15, 2013·Immunological Reviews·Sascha RutzWenjun Ouyang
Dec 16, 2011·Immunological Reviews·Gérard Eberl
Sep 6, 2012·European Journal of Immunology·Caroline E SuttonKingston H G Mills

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.