Interleukin-2, anti-interleukin-2 receptor antibody, and activation of macrophages

Cellular Immunology
M Belosevic, C A Nacy

Abstract

Macrophages treated with IFN-gamma and IL-2 before exposure to parasites develop the ability to resist infection with amastigotes of Leishmania major. In this cooperative interaction of cytokines, IL-2 can be replaced with any of several mAb directed against the beta chain of the IL-2 receptor, but not by antibodies to a number of other cell receptors or antigens. Thus, antibodies to the IL-2 receptor act as agonists of IL-2 in the induction of a biologic activity in macrophages, and macrophages, a nonproliferating cell type, respond to signals transmitted through the beta chain of the IL-2 receptor.

References

Jan 1, 1987·The Journal of Experimental Medicine·K TeshigawaraK A Smith
Sep 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·T R MalekE M Shevach

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Citations

Jun 1, 1991·Current Opinion in Immunology·C A Nacy, M S Meltzer
Jan 1, 1993·Mediators of Inflammation·S E SmithJ G McCormack
Dec 19, 2019·Pediatric Blood & Cancer·Yasunori IidaShunji Hasegawa

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