Interleukin-2, but not interleukin-15, is required to terminate experimentally induced clonal T-cell anergy

Scandinavian Journal of Immunology
S Bendiksen, O P Rekvig

Abstract

It has been demonstrated that T cells stimulated with nucleosome-polyomavirus T-antigen (self-nonself) complexes, but not nucleosomes, activate autoimmune nucleosome-specific T cells. As these cells may be naïve, such observations do not show that anergic T cells are reactivated. To understand the regulation of autoimmunity, this is important to assess, and this is the focus of this study. T-cell anergy was induced by antigen stimulation in the presence of antibodies to the costimulatory molecules CD80/CD86. Requirements for the reactivation of anergic T cells were analysed by the ability of antigen and interleukin-2 (IL-2) or IL-15 to increase T-cell proliferation and IL-2 transcription. Data demonstrate that stimulation of T cells with T-antigen and anti-CD80/86 antibodies promotes long-lasting clonal T-cell anergy. While T-antigen did not reactivate anergic T cells, proliferation and upregulation of IL-2 gene transcription was initiated by stimulation with antigen, costimulation and IL-2 added to the cultures. Proliferation per se was not sufficient to promote the reactivation of anergic T cells, as both IL-2 and IL-15 induced proliferation, while antigen and IL-2, but not IL-15, upregulated IL-2 mRNA levels. These data demo...Continue Reading

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Citations

Aug 26, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·Pål RustadUNKNOWN Nordic Reference Interval Project 2000
Feb 8, 2008·Cancer Immunology, Immunotherapy : CII·Willem Den OtterJan Willem Koten
Nov 8, 2008·Molecular Immunology·Myrianne Duré, Fernando Macian
Mar 28, 2007·Heart Failure Clinics·Sally Huber
Dec 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Signy BendiksenOle Petter Rekvig
Sep 21, 2019·Immunological Reviews·Shuangjin YuXunrong Luo

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