PMID: 6975325Dec 1, 1981Paper

Interleukin 2 deficiency is a common feature of autoimmune mice

The Journal of Immunology : Official Journal of the American Association of Immunologists
M DauphineeN Talal

Abstract

IL 2 production was studied in autoimmune mice to assess the role of this lymphokine in the pathogenesis of murine lupus. Spleen and lymph node cells from autoimmune-susceptible mice show an age-dependent loss in the ability to produce functional IL 2. This defect correlates with disease expression and is most severe in MLR/Mp-Ipr/Ipr mice. MLR/Mp-Ipr/Ipr thymocytes gradually lose responsiveness to IL 2 with age. These results suggest that the immunoregulatory abnormalities of autoimmune mice may be due in part to IL 2 deficiency.

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