Apr 3, 2012

Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation

Immunity
André Ballesteros-TatoTroy D Randall

Abstract

T follicular helper (Tfh) cells promote T cell-dependent humoral immune responses by providing T cell help to B cells and by promoting germinal center (GC) formation and long-lived antibody responses. However, the cellular and molecular mechanisms that control Tfh cell differentiation in vivo are incompletely understood. Here we show that interleukin-2 (IL-2) administration impaired influenza-specific GCs, long-lived IgG responses, and Tfh cells. IL-2 did not directly inhibit GC formation, but instead suppressed the differentiation of Tfh cells, thereby hindering the maintenance of influenza-specific GC B cells. Our data demonstrate that IL-2 is a critical factor that regulates successful Tfh and B cell responses in vivo and regulates Tfh cell development.

Mentioned in this Paper

Immune Response
Mucocutaneous Lymph Node Syndrome
Flow Cytometry
Biochemical Pathway
EOMES gene
Il2ra protein, mouse
Richieri Costa Guion-Almeida Syndrome
Lymphoma, Non-Hodgkin
Structure of Germinal Center of Lymph Node
Immune Effector Cell

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