Interleukin-2 inhibits polarization to T helper type 1 cells and prevents mouse acute graft-versus-host disease through up-regulating suppressors of cytokine signalling-3 expression of naive CD4+ T cells.

Clinical and Experimental Immunology
J ZhaoY Xie

Abstract

T helper type 1 (Th1)-type polarization plays a critical role in the pathophysiology of acute graft-versus-host disease (aGVHD). The differentiation of T cells into this subtype is dictated by the nature of the donor naive CD4(+) T cell-host antigen presenting cell (APC) interaction. Suppressors of cytokine signalling (SOCS) are a family of molecules that act as negative regulators for cytokine signalling, which regulate the negative cytokine signalling pathway through inhibiting the cytokine-induced Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway. Studies have shown that SOCS proteins are key physiological regulators of both innate and adaptive immunity. These molecules are essential for T cell development and differentiation. SOCS-3 can inhibit polarization to Th1 and contribute to polarization to Th2. In this study, we found that interleukin (IL)-2 pre-incubation of C57BL/6 naive CD4(+) T cells could up-regulate the expression of SOCS-3. Naive CD4(+) T cells constitutively expressed low levels of SOCS-3 mRNA. SOCS-3 mRNA began to rise after 4 h, and reached peak level at 6 h. At 8 h it began to decrease. High expression of SOCS-3 mRNA induced by IL-2 could inhibit the proliferation of naive C...Continue Reading

References

Jun 26, 1997·Nature·R StarrD J Hilton
Oct 20, 1999·Cellular and Molecular Life Sciences : CMLS·D J Hilton
Oct 29, 2000·Annals of the Rheumatic Diseases·J C Morris, T A Waldmann
May 18, 2001·Nature·F R Appelbaum
May 22, 2001·AIDS Patient Care and STDs·S Pahwa, M Morales
Mar 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Charles E EgwuaguIgal Gery
Jun 4, 2002·Nature Medicine·Takanori TeshimaJames L M Ferrara
Jul 3, 2002·Nature Reviews. Immunology·Warren S Alexander
Jul 3, 2002·The Journal of Experimental Medicine·Sean DiehlMercedes Rincón
Oct 31, 2002·International Immunology·Minoru FujimotoTetsuji Naka
Jan 9, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ann L CornishRobyn Starr
Feb 20, 2003·The Journal of Experimental Medicine·Akira MatsumotoMasato Kubo
Jun 5, 2003·The Journal of Biological Chemistry·Cheng-Rong YuCharles E Egwuagu
Jul 4, 2003·The Journal of Clinical Investigation·Britt E AndersonWarren D Shlomchik
Jul 9, 2003·Nature Medicine·Yoh-ichi SekiMasato Kubo
Jul 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Takayuki YoshimotoJunichiro Mizuguchi
Sep 6, 2003·Blood·Hans-Jochem KolbDolores J Schendel
Mar 23, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brad H Nelson
May 21, 2005·The International Journal of Biochemistry & Cell Biology·Joel Fletcher, Robyn Starr
Mar 16, 2007·British Journal of Haematology·Edward S Morris, Geoffrey R Hill
May 26, 2007·Nature Reviews. Immunology·Akihiko YoshimuraMasato Kubo

❮ Previous
Next ❯

Citations

Nov 3, 2011·Immunology·Camille A Knosp, James A Johnston
Aug 2, 2015·Immunity·Gail D SckiselWilliam J Murphy
Oct 11, 2019·American Journal of Reproductive Immunology : AJRI·Li ShixiangGuanyou Huang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.