PMID: 2499617May 1, 1989Paper

Interleukin-2, interleukin-2 receptor and gamma-interferon synthesis by peripheral blood mononuclear cells in chronic hepatitis delta virus infection

Journal of Hepatology
S MagrinC Ausiello

Abstract

The behaviour of the immune system during liver damage caused by chronic hepatitis delta virus (HDV) infection was evaluated by assessing, in 16 patients with HBsAg+ chronic liver disease and HDV superinfection (15 HBeAg-, 1 HBeAg+), phytohaemagglutinin (PHA)-induced interleukin-2 synthesis and interleukin-2 receptor expression, PHA and staphylococcal enterotoxin B (SEB)-induced gamma-interferon synthesis and, in some cases, the presence of hepatitis B virus DNA (HBV-DNA) within peripheral blood mononuclear cells (PBMC). The results were compared to those obtained in 13 patients without HBV replication (i.e., serum HBV-DNA and liver HBcAg-negative), in 15 with HBV replication (i.e., serum HBV-DNA and/or liver HBcAg-positive) with chronic liver disease without HDV superinfection, and in 15 HBsAg-negative healthy control subjects. The lymphokine pattern in HDV infection was comparable to that of healthy subjects and of HBV non-replicating patients without HDV superinfection. Interleukin-2 receptor expression and gamma-interferon synthesis were however significantly decreased in HDV-negative patients with active HBV replication. HBV-DNA was detected in PBMC from 8 of 23 patients, without any correlation with the lymphokine pattern...Continue Reading

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Citations

Dec 1, 1991·Journal of Medical Virology·S GuptaA G Redeker
May 23, 2018·Biotechnology & Genetic Engineering Reviews·Shivali S Joshi, Carla S Coffin
Feb 11, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Michiel C WarléHugo W Tilanus
Jan 30, 2019·Journal of Gastroenterology and Hepatology·Elizabeth C TownsendTheo Heller
Jan 11, 2014·World Journal of Hepatology·Zaigham Abbas, Rafia Afzal

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