Interleukin-2 potentiates novelty- and GBR 12909-induced exploratory activity

Brain Research
S Zalcman

Abstract

Interleukin (IL)-2 is a cytokine that influences exploratory behavior and central dopamine activity in rodents, and induces schizophrenic-like behavior and cognitive deficits in humans. We presently report that a single i.p. injection of murine IL-2 (0.05-0.80 microg/mouse) induced significant increases in novelty-induced locomotion and exploration in BALB/c mice. These measures were not significantly altered in mice that were pre-exposed to the test cage prior to cytokine injection. The IL-2-induced behavioral changes were not further augmented by repeated intermittent injections (five daily i.p. injections; 0.4 microg/mouse), however. Nonetheless, during the treatment period, activity scores of IL-2-treated mice significantly exceeded those of mice receiving saline; hence, repeated injections of IL-2 induced a persistent behavioral activation. IL-2 treatment also increased sensitivity to the behavior-stimulating effects of GBR 12909, a highly selective dopamine uptake inhibitor. This effect was a very long-lasting one since the dopamine agonist was administered 6 weeks after cessation of IL-2 treatment. The latter finding indicates that IL-2 interacts with the mesolimbic dopamine system, changing its sensitivity to seemingly ...Continue Reading

Citations

Jan 11, 2003·Clinical and Diagnostic Laboratory Immunology·Jesse CushmanJohn M Petitto
Sep 7, 2007·Annals of the New York Academy of Sciences·Nicholas M PonzioTim Kreider
Dec 3, 2014·Acta Neuropsychiatrica·Livia C M RodriguesAlline Cristina Campos
Nov 16, 2004·Annals of the New York Academy of Sciences·Kiyofumi Yamada, Toshitaka Nabeshima
Apr 17, 2003·Neuroscience Letters·Cornelius R -PawlakArtur Bauhofer
Jun 25, 2020·Journal of Neuroimmunology·Aline Silva de MirandaAntônio Lúcio Teixeira

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