Interleukin-2 Receptor and Angiotensin-Converting Enzyme as Markers for Ocular Sarcoidosis

PloS One
Enken GundlachThomas Ness

Abstract

To study the impact of soluble IL2 receptor (sIL2R), chest x-ray (CxR), and angiotensin-converting enzyme (ACE) as markers for sarcoidosis in uveitis patients. Retrospective study. Serum concentrations of sIL2R and ACE were measured in patients with active uveitis. Those with elevated sIL2R and /or ACE values were examined for suspected systemic sarcoidosis. Our main outcome parameters were the specificity and sensitivity of sIL2R, CxR and ACE in screening for ocular sarcoidosis. We measured 261 patients with uveitis for sarcoidosis using sIL2R and ACE between January 2008 and November 2011; sarcoidosis was been diagnosed using other tests (e.g. computer tomography, brochoalveolar lavage, biopsy) in 41 of 53 patients with elevated sIL2R values (>639 U/ml) and in one patient with normal sIL2R (582 U/ml). Their mean sIL2R value was 1310 U/ml, extending from 582 to 8659 U/ml. Only 9 patients, however, presented elevated ACE (>82 U/l). Their mean ACE value was 116.4 U/l, ranging from 84.1 to 175.5 U/l. IL2R specificity was 94% with 98% sensitivity. In contrast, ACE had a specificity of 99.5%, but a sensitivity of only 22%; the chest x-ray had a specificity of 100% with 50% sensitivity in detecting sarcoidosis. We observed the entir...Continue Reading

References

Jan 1, 1992·Current Eye Research·P I Murray, D W Young
Dec 1, 1991·The American Review of Respiratory Disease·J Müller-QuernheimR Ferlinz
Jan 1, 1990·Current Eye Research·E Arocker-MettingerG Grabner
Jan 1, 1989·Annals of Clinical Biochemistry·P R Studdy, R Bird
Apr 1, 1974·American Journal of Epidemiology·P E Sartwell, L B Edwards
Sep 1, 1995·American Journal of Respiratory and Critical Care Medicine·L ZhengU Costabel
Aug 1, 1993·The American Review of Respiratory Disease·S GilbertG W Hunninghake
Jan 1, 1993·American Journal of Ophthalmology·D BenEzraV Barak
Mar 1, 1993·Clinical and Experimental Immunology·C A StegemanC G Kallenberg
Apr 24, 1997·The New England Journal of Medicine·L S NewmanL A Maier
Dec 31, 1997·American Journal of Respiratory and Critical Care Medicine·M W ZiegenhagenJ Müller-Quernheim
Nov 5, 1997·The American Journal of Nursing·B S Zitkus
Dec 28, 1999·The British Journal of Ophthalmology·A Rothova
Mar 4, 2000·Retina·J E Thorne, A J Brucker
Mar 29, 2003·The European Respiratory Journal·M W ZiegenhagenJ Müller-Quernheim
Jan 1, 1950·Cancer·W J YOUDEN
Mar 5, 2005·Ophthalmic Research·Necip TorunUwe Pleyer
Oct 1, 2005·American Journal of Ophthalmology·Douglas A JabsUNKNOWN Standardization of Uveitis Nomenclature (SUN) Working Group
Mar 3, 2007·Seminars in Respiratory and Critical Care Medicine·Marc A Judson
Apr 3, 2007·Japanese Journal of Ophthalmology·Tatsushi KawaguchiManabu Mochizuki
Aug 9, 2007·Proceedings of the American Thoracic Society·Milton D Rossman, Mary Elizabeth Kreider
Sep 25, 2007·Orvosi hetilap·Tamás Kullmann
Nov 3, 2007·American Journal of Respiratory and Critical Care Medicine·Antje PrasseJoachim Müller-Quernheim
Nov 23, 2007·The New England Journal of Medicine·Michael C IannuzziAlvin S Teirstein
Aug 1, 1949·American Journal of Clinical Pathology·W RICKER, M CLARK
Oct 1, 2008·La Revue de médecine interne·S AbadA-P Brézin
Jul 9, 2009·Ocular Immunology and Inflammation·Carl P HerbortUNKNOWN members of Scientific Committee of First International Workshop on Ocular Sarcoidosis
Jan 19, 2010·Chest·Seigo MiyoshiJitsuo Higaki
Feb 5, 2010·Ocular Immunology and Inflammation·Denis Wakefield, Manfred Zierhut
Jun 18, 2010·Journal of Neurology·Hela-Felicitas PetereitAndrea Rubbert
Oct 26, 2010·La Revue de médecine interne·L VarronP Sève
Nov 3, 2010·American Journal of Respiratory and Critical Care Medicine·Robert P BaughmanMarc A Judson
Nov 26, 2010·Ophthalmic Research·Arnd HeiligenhausMathias Schrenk
Apr 13, 2011·Archives of Ophthalmology·Andrea D BirnbaumDebra A Goldstein
Oct 20, 2011·European Journal of Gastroenterology & Hepatology·Johanna CremersGer Koek
Sep 18, 2012·BMC Pulmonary Medicine·Rémy L M MostardMarjolein Drent
Aug 6, 2013·Acta Ophthalmologica·Rafael S GrajewskiLudwig M Heindl
Sep 26, 2013·Ocular Immunology and Inflammation·L E CaspersO Michel

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Citations

Apr 28, 2016·Expert Review of Clinical Immunology·Lesley Ann Saketkoo, Robert P Baughman
Jun 15, 2016·Case Reports in Ophthalmological Medicine·Sílvia Miguéis Picado PetrarolhaPedro Martins Tavares Scianni Morais
Nov 1, 2016·Experimental Biology and Medicine·Karen M DoerschM Karen Newell-Rogers
May 19, 2017·Zeitschrift für Rheumatologie·C Springer-Wanner, T Brauns
Dec 3, 2016·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·J G Garweg
Jan 28, 2017·Scientific Reports·J J W KuiperT R D J Radstake
Jan 21, 2018·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·Annabelle EckertUwe Pleyer
Jan 12, 2019·Expert Review of Clinical Immunology·Manuel Ramos-CasalsPilar Brito-Zerón
Jun 18, 2017·Current Opinion in Pulmonary Medicine·Sung J YangJames T Rosenbaum
Feb 25, 2019·The British Journal of Ophthalmology·Manabu MochizukiUNKNOWN International Workshop on Ocular Sarcoidosis Study Group
Aug 11, 2020·Seminars in Respiratory and Critical Care Medicine·Pascal SèveThomas El Jammal
Sep 3, 2020·Investigative Ophthalmology & Visual Science·Masaki AsakageHiroshi Goto
Sep 9, 2020·Current Opinion in Ophthalmology·De-Kuang Hwang, Shwu-Jiuan Sheu
Nov 18, 2017·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·E GundlachU Pleyer
Apr 30, 2017·Orphanet Journal of Rare Diseases·Thomas NessSonja Heinzelmann
Aug 3, 2020·International Ophthalmology·Rosanna DammaccoFranco Dammacco
Dec 10, 2020·Journal of Clinical Medicine·Hiroyuki ShimizuHiroshi Goto
Jan 10, 2021·Japanese Journal of Ophthalmology·Kayo SuzukiSusumu Ishida
Sep 7, 2016·Deutsches Ärzteblatt International·Antje Prasse
Jan 21, 2021·Journal of Clinical Medicine·Thomas El JammalPascal Sève
Feb 3, 2021·American Journal of Ophthalmology·Aniruddha AgarwalVishali Gupta
Feb 13, 2021·Survey of Ophthalmology·K Matthew McKayRussell N Van Gelder
Oct 4, 2020·Current Opinion in Ophthalmology·De-Kuang Hwang, Shwu-Jiuan Sheu
Apr 13, 2021·American Journal of Ophthalmology·UNKNOWN Standardization of Uveitis Nomenclature (SUN) Working Group
Jul 13, 2021·Ophthalmic Genetics·Filipa G RodriguesMark Westcott
Aug 25, 2020·Respiratory Medicine·Ying ZhouHuiping Li

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Methods Mentioned

BETA
biopsy
biopsies
bronchoalveolar lavage
bronchoalveolar
lavage

Software Mentioned

Graph
Prism

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