Interleukin 2 receptor expression by T cells in human aging

Cellular Immunology
F M OrsonD L Nelson

Abstract

Aged individuals have depressed cell-mediated immunity and diminished T cell proliferation to mitogenic and antigenic stimuli. Because T cell responses depend on the surface expression and normal function of interleukin 2 receptors, we measured the quantities and affinities of cell surface IL-2R and the amount of soluble IL-2R alpha chain (p55) release in vitro in PHA-stimulated mononuclear cells from healthy aged (greater than or equal to 65 years old) and young (less than or equal to 39 years old) donors. At the peak of the PHA response, the fraction of cells expressing IL-2R alpha chain (CD25+) was lower in the aged (43% vs 56%, P = 0.033). Relative to the lower proliferation and CD25 expression, old donor cells released unexpectedly high quantities of soluble alpha chain into culture supernatants. However, the average affinities and the mean numbers of high- and low-affinity surface receptors per CD25+ cell were equivalent in cells from eight pairs of aged and young donors (1850 vs 1586 high affinity, and 20,655 vs 23,466 low affinity, P greater than 0.2 for both). The soluble IL-2R released by stimulated cells had no effect on proliferative responses, because addition of saturating doses of exogenous recombinant IL-2 did n...Continue Reading

References

Nov 1, 1985·Mechanisms of Ageing and Development·G W CanonicaH H Fudenberg
Mar 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A M WeissmanR D Klausner
Jan 1, 1987·The Journal of Experimental Medicine·K TeshigawaraK A Smith
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M TsudoT A Waldmann
Nov 1, 1985·Mechanisms of Ageing and Development·H RabinowichA Klajman
Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·W J LeonardW C Greene

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Citations

Mar 28, 1996·International Journal of Cancer. Journal International Du Cancer·A ChakrabortyU Chattopadhyay
Jan 1, 1992·International Journal of Clinical & Laboratory Research·G SemenzatoR Zambello
Oct 1, 1998·Age·E D Bernstein, D M Murasko
Sep 1, 1991·Mechanisms of Ageing and Development·L GuidiP Carbonin
Aug 8, 1995·Mechanisms of Ageing and Development·K Y TuK S Matthews
Oct 1, 1992·Mutation Research·M E GonsebattP Ostrosky-Wegman
Jul 27, 2001·Mechanisms of Ageing and Development·T FülöpG Dupuis
Jul 16, 1999·Mechanisms of Ageing and Development·B Chakravarti, G N Abraham
Aug 17, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·M E Ginn-Pease, R L Whisler
Feb 26, 1998·Immunological Reviews·G Doria, D Frasca
Sep 1, 1990·Arthritis and Rheumatism·K S BarronF M Orson
May 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sara A JohnsonJohn C Cambier
Jan 1, 1995·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·S MotojimaS Makino

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