PMID: 2117107Jan 1, 1990Paper

Interleukin-2 therapy for human cancer

Lung
Q G van Hoesel

Abstract

The concept of immunotherapy is evolving from nonspecific, haphazard stimulation of the immune apparatus to more specific and controlled manipulation of the immune system. IL-2 gives the opportunity to exert influence on the cellular immune system. Why LAK cells are able to lyse tumor cells and leave normal cells intact is not known. How LAK cells behave after reinfusion is not known; are they able to migrate to tumor sites? Can improvements be made in scheduling in order to decrease toxicity and to enhance efficacy? But first of all, the question arises whether the tremendous efforts required by adoptive transfer, in terms of toxicity, logistics, and money, are outweighed by the therapeutic results. For clinical practice inside the frontier of oncology, continuous infusion of IL-2 at an intermediate dose is a quite attractive option in finding a balance between efforts and results.

References

Jul 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P A PaciucciR Odchimar
Sep 1, 1988·Advances in Contraception : the Official Journal of the Society for the Advancement of Contraception·S S Sheth
Feb 1, 1988·Immunology Today·A O'GarraJ Christiansen
Feb 1, 1988·Immunology Today·K A Smith
Apr 9, 1987·The New England Journal of Medicine·W H WestR K Oldham
Jan 1, 1986·Springer Seminars in Immunopathology·M R ShalabyM A Palladino
Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·W J LeonardW C Greene

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Citations

Sep 27, 2018·The American Journal of Hospice & Palliative Care·Debra L WiegandGiora Netzer
Nov 5, 2016·International Journal of Health Services : Planning, Administration, Evaluation·Sarah MousaidChristophe Vanroelen
Nov 6, 2009·Oncology Nursing Forum·Erika Metzler SawinRichard H Steeves
Sep 26, 2008·The Journal of the Royal Society for the Promotion of Health·Jim McKenna, Alison Frances Ludwig
Aug 23, 2007·The Journal of the Royal Society for the Promotion of Health·Jim McKenna, Claire Hammond
Aug 5, 2005·Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses·Maria BjörkInger Hallström
Aug 17, 2005·Scandinavian Journal of Caring Sciences·Elisabeth O C Hall

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