Interleukin 20 regulates dendritic cell migration and expression of co-stimulatory molecules

Molecular and Cellular Therapies
Rikke BechThomas Vorup-Jensen

Abstract

Psoriasis is an inflammatory disease characterized by leukocyte skin infiltration. Interestingly, recent works suggest that the migration of dendritic cells (DCs) is abnormal in psoriatic skin. DCs have significant role in regulating the function of T lymphocytes, at least in part influenced by the local environment of cytokines. In psoriatic skin lesions the expression of IL-20 is highly up-regulated. It is unclear if this cytokine has any influence on DCs. Here, we investigated the influence of IL-20 in monocyte-derived dendritic cell (MDDCs) in vitro. This work addressed IL-20 effects on DC maturation, receptor expression and signaling. By use of extra cellular matrix components mimicking the skin environment, we also studied the functional effects of IL-20 on the chemotactic migration of DCs. Based on the recent finding that CD18 integrin are shed during migration of myeloid leukocytes, the concentration of these adhesion molecules was measured in MDDCs culture supernatants post migration. Following stimulation with IL-20, immature human MDDCs enhanced the expression of the co-stimulatory molecule CD86, further enabling activation of the p38 MAPK, but not the STAT3, pathway. IL-20 increased the migration of MDDCs in a bipha...Continue Reading

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Citations

Apr 21, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Portia GoughSandip K Datta
Sep 28, 2018·Journal of Leukocyte Biology·Jun ChenWai Po Chong
Jun 12, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bing-You YangHai-Xue Kuang

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Methods Mentioned

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xenografts
flow cytometry
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Leica Application Suite

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