Interleukin 21 (IL-21)/microRNA-29 (miR-29) axis is associated with natural resistance to HIV-1 infection.

AIDS
Paula A S OrtegaMara Biasin

Abstract

Interleukin-21 (IL-21) modulates HIV-1 infection through the elicitation of different antiviral mechanisms, including Th17 lineage commitment and induction of microRNA (miR)-29, a miRNA endowed with anti-HIV activity. As miR-29 expression is significantly increased in HIV-1-exposed seronegative individuals (HESN), we investigated the role of miR-29/IL21 axis in the natural control of HIV-1 infection. Peripheral blood mononuclear cells (PBMCs) isolated from 15 Italian sexually exposed HESN and 15 HIV-unexposed healthy controls were in-vitro infected with an R5-tropic HIV-1Ba-L strain. Seven days post HIV-1 infection we evaluated: 1) p24 production (ELISA); 2) CD4/IL-21 and CD4/IL-17 T lymphocytes (FACS); 3) IL-17 concentration in supernatants (ELISA); and 4) IL-6, IL-17, IL-21, and miR-29a,b,c expression by CD4 T lymphocytes as well as perforin and granzyme by peripheral blood mononuclear cells (qPCR). The same analyses were performed on the 15 HIV-positive partners. At baseline IL-6 expression alone was increased in HESN compared to healthy controls. Seven days after in-vitro HIV-1 infection, nevertheless, differences emerged. Thus, CD4/IL21 and CD4/IL17 T lymphocytes, as well as IL-21 and IL-17 expression and production were s...Continue Reading

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Citations

Apr 6, 2019·Journal of Cellular Physiology·Mohsen AlizadehBehzad Baradaran
Feb 23, 2020·Expert Review of Clinical Immunology·Claudio FeniziaMara Biasin
Oct 4, 2020·Annals of the New York Academy of Sciences·Catherine TamaletPhilippe Colson
Dec 10, 2019·Microbes and Infection·Paula Andrea Serna-OrtegaMara Biasin
Feb 3, 2021·Journal of Cellular Biochemistry·Masahiro HoritaLouise A Stephen
Feb 24, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Irma SaulleMara Biasin
Apr 14, 2021·Current Hypertension Reports·Tashlen AbelThajasvarie Naicker
Sep 10, 2020·Current HIV Research·Mohsen MoghoofeiSeyed Hamidreza Monavari

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