Interleukin-21 stimulates antigen uptake, protease activity, survival and induction of CD4+ T cell proliferation by murine macrophages

Clinical and Experimental Immunology
R RückertK Brandt

Abstract

Interleukin (IL)-21 is a T cell-derived cytokine which uses a heterodimeric receptor, composed of the common gamma-chain (CD132) and an IL-21Ralpha-chain. IL-21 activates lymphoid T and B cells, modulates antibody production but also suppresses maturation of myeloid dendritic cells; however, its role in the differentiation and function of other myeloid cells remains less clear. In this study we analysed IL-21/IL-21Ralpha effects on macrophage (MPhi) differentiation and function. MPhi could be generated readily from bone marrow with MPhi-colony-stimulating factor in the presence of IL-21 (designated IL-21MPhi) or from IL-21Ralpha-/- mice. IL-21Ralpha-/- mice had normal MPhi numbers, suggesting a non-essential role of both IL-21 and the IL-21Ralpha for MPhi generation. We could demonstrate that mature MPhi express the IL-21Ralpha and the common gamma-chain. However, short-term IL-21 stimulation did not enhance MPhi proliferation but induced anti-apoptotic cell-cycle regulators p21(waf1)/p27(Kip1) and expression of suppressors of cytokine signalling (SOCS)2/SOCS3. Moreover, IL-21 enhanced phagocytosis by MPhi via IL-21Ralpha signalling and supports protease activity and matrix metalloproteinase 12 expression. Stimulating MPhi with...Continue Reading

References

Jun 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·H AsaoK Sugamura
Aug 2, 2003·Blood·Katja BrandtRené Rückert
Dec 17, 2003·The Journal of Investigative Dermatology·Katja BrandtRené Rückert
Jun 3, 2004·International Immunology·Akihiro KimuraTadamitsu Kishimoto
Aug 6, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yongqing LiCassian Yee
Sep 3, 2005·Nature Reviews. Immunology·Warren J Leonard, Rosanne Spolski
Jun 17, 2006·The Journal of Clinical Investigation·John PesceThomas A Wynn
May 19, 2007·Cytokine & Growth Factor Reviews·Katja BrandtRené Rückert
Jun 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kerry A Casey, Matthew F Mescher
Jun 8, 2007·Journal of Leukocyte Biology·Valérie OstiguyNathalie Labrecque
Aug 28, 2007·Annals of the Rheumatic Diseases·A H SawalhaJ B Harley
Sep 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brianne R BarkerNorman L Letvin

❮ Previous
Next ❯

Citations

Dec 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Magdalena HuberMichael Lohoff
Oct 23, 2009·Tissue Antigens·H Søndergaard, K Skak
Jun 24, 2015·Clinical and Experimental Immunology·L S K Walker, M von Herrath
Jul 6, 2012·Cytokine & Growth Factor Reviews·Suresh PallikkuthSavita Pahwa
Sep 8, 2010·Microbes and Infection·John S YiAllan J Zajac
Feb 12, 2009·Diabetes·Andrew P R SutherlandMatthias von Herrath
Dec 17, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tiehui WangChristopher J Secombes
Oct 25, 2016·Clinical and Experimental Immunology·F Vallières, D Girard
Apr 17, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Meng XuShengdian Wang
Oct 21, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Henrik SchmidtPoul F Geertsen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.