Interleukin-22 contributes to liver regeneration in mice with concanavalin A-induced hepatitis after hepatectomy

World Journal of Gastroenterology : WJG
Ya-Min ZhangZhong-Yang Shen

Abstract

To investigate the therapeutic effects and mechanisms of interleukin (IL)-22 in liver regeneration in mice with concanavalin A (ConA)-induced liver injury following 70% hepatectomy. Mice were injected intravenously with ConA at 10 μg/g body weight 4 d before 70% hepatectomy to create a hepatitis model, and recombinant IL-22 was injected at 0.125 μg/g body weight 30 min prior to 70% hepatectomy to create a therapy model. Control animals received an intravenous injection of an identical volume of normal saline. IL-22 treatment prior to 70% hepatectomy performed under general anesthesia resulted in reductions in the biochemical and histological evidence of liver injury, earlier proliferating cell nuclear antigen expression and accelerated recovery of liver mass. IL-22 pretreatment also significantly induced signal transducer and activator of transcription factor 3 (STAT3) activation and increased the expression of a variety of mitogenic proteins, such as Cyclin D1. Furthermore, alpha fetal protein mRNA expression was significantly elevated after IL-22 treatment. In this study, we demonstrated that IL-22 is a survival factor for hepatocytes and prevents and repairs liver injury by enhancing pro-growth pathways via STAT3 activation....Continue Reading

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Citations

May 18, 2016·The Tohoku Journal of Experimental Medicine·Kazuhiro TakahashiNobuhiro Ohkohchi
Aug 9, 2017·World Journal of Gastroenterology : WJG·Ching-Pin LinChih-Yen Chen
Apr 15, 2021·Seminars in Immunopathology·Jöran LückeSamuel Huber

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