Interleukin-22 Polymorphisms in Plasmodium falciparum -Infected Malaria Patients

Mediators of Inflammation
Nada H AljarbaAhmed A Al-Qahtani

Abstract

Background and Objectives. Malaria infection, caused by Plasmodium falciparum, is the most lethal and frequently culminates in severe clinical complications. Interleukin-22 (IL-22) has been implicated in several diseases including malaria. The objective of this study was to investigate the role of IL-22 gene polymorphisms in P. falciparum infection. Material and Methods. Ten single-nucleotide polymorphisms (SNPs), rs976748, rs1179246, rs2046068, rs1182844, rs2227508, rs2227513, rs2227478, rs2227481, rs2227491, and rs2227483, of IL-22 gene were genotyped through PCR-based assays of 250 P. falciparum infection. IL-22 gene promoter activity. We found that the rs2227481 TT genotype (odds ratio 0.254, confidence interval = 0.097-0.663, P. P. falciparum infection. P. P. P. P. The study suggests that IL-22 polymorphisms in rs2227481 and rs2227483 could contribute to protection against P. falciparum infection. IL-22 gene promoter activity.

References

Jan 1, 1996·Biochimie·A Jacquier
Aug 22, 2003·Critical Care : the Official Journal of the Critical Care Forum·Andrej TrampuzRajesh M Prabhu
Jul 8, 2005·American Journal of Human Genetics·Dominic P Kwiatkowski
Jul 30, 2008·The Journal of Infectious Diseases·Fabiana M S LeorattiRajendranath Ramasawmy
May 28, 2009·Experimental Dermatology·Wolfgang WegerWolfgang Salmhofer
Nov 26, 2010·Cytokine & Growth Factor Reviews·Wenjun Ouyang
Sep 21, 2011·Malaria Journal·Adel DrissJonathan K Stiles
May 9, 2012·Frontiers in Immunology·Béatris MastelicJean Langhorne
Jun 19, 2012·Mediterranean Journal of Hematology and Infectious Diseases·Alessandro Bartoloni, Lorenzo Zammarchi
Sep 7, 2012·PloS One·Penghua WangErol Fikrig
Oct 24, 2012·Mediators of Inflammation·Shujuan LiYanfang Jiang
Jan 15, 2013·Journal of Tropical Medicine·Vitor R R de MendonçaManoel Barral-Netto
May 15, 2013·Journal of Dermatological Science·Hidehisa SaekiMayumi Tamari
May 9, 2014·The New England Journal of Medicine·Bronner P GonçalvesPatrick E Duffy
Oct 10, 2014·Diagnostic Pathology·Hong Gang ChiYing Zou
Jan 4, 2015·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Jun HuYing Peng
Feb 24, 2015·Annual Review of Immunology·Jarrod A DudakovMarcel R M van den Brink
Nov 11, 2015·Malaria Journal·Ibrahim M El HassanRobert W Snow
Aug 26, 2017·International Journal of Endocrinology·Rong-Hua SongJin-An Zhang
Aug 9, 2018·Malaria Journal·Rasha Hassan SolimanJosé Miguel Rubio
Aug 24, 2018·F1000Research·Mario ReckerCaroline O Buckee

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Citations

Apr 15, 2021·Seminars in Immunopathology·Jöran LückeSamuel Huber
Aug 5, 2021·Journal of Inflammation Research·Alaa U AlRuwaisanAhmed A Al-Qahtani

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Methods Mentioned

BETA
SMA
genotyping
PCR
electrophoresis

Software Mentioned

Primer3
Haploview

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