Interleukin 23/interleukin 17 axis activated by Mycobacterium avium complex (MAC) is attenuated in patients with MAC-lung disease

Tuberculosis
Chin-Chung ShuChong-Jen Yu

Abstract

Mycobacterium avium complex (MAC)-lung disease (LD) is increasing in patients without human immunodeficiency virus infection. However, data on host vulnerability to MAC-related immune responses, and in particular the interleukin (IL)-23/IL-17 axis, are lacking. We enrolled 50 patients with MAC-LD, 25 age-matched patients with tuberculosis (TB) and 25 controls. We measured levels of plasma cytokines, and studied IL-12/IL-17 responses in macrophage and lymphocyte activation to MAC. The plasma level of IL-17 in the MAC group was higher than in the TB and control groups. In in-vitro macrophage stimulation, the expression of IL-23 in macrophages was similar in the patients with MAC-LD and controls, although the expression of IL-12 p40 was lower in the patients with MAC-LD. In assays of lymphocyte activation, IL-17 was induced by MAC-primed macrophages, but its level was lower in the patients with MAC-LD and TB than in the controls. The expression of programmed death (PD)-1 receptor was higher in CD4+IL17A+ lymphocytes in the patients with MAC-LD, and the production of IL-17 was significantly increased by blockade of PD-1 and PD-ligand 1. MAC induced a similar expression of IL-23 from macrophages in the patients with MAC-LD compared ...Continue Reading

Citations

Nov 7, 2019·The Journal of Dermatological Treatment·Vipawee S ChatJashin J Wu
Feb 27, 2020·Current Opinion in Pulmonary Medicine·Grant Waterer
Apr 20, 2019·The European Respiratory Journal·Anne HuibertsWouter Hoefsloot
Jun 22, 2019·The European Respiratory Journal·Steven CowmanMichael R Loebinger
Dec 3, 2020·ERJ Open Research·Milou M F SchuurbiersWouter Hoefsloot
Feb 2, 2021·Frontiers in Cellular and Infection Microbiology·Suji KimHan Sang Yoo

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