Interleukin-31 and Chronic Pruritus of Unknown Origin

Biomarker Insights
Kanin SalaoSuteeraporn Chaowattanapanit

Abstract

Chronic pruritus of unknown origin (CPUO) is a refractory condition. The expression of Interleukin-31 (IL-31), a major pruritogenic cytokine, in CPUO patients has not been investigated. This study aimed to investigate the potential association of IL-31 with CPUO. This was a cross-sectional, analytical study. Patients diagnosed with CPUO and healthy subjects were included at a ratio of 1:2. Serum IL-31 levels were measured in both groups and compared. There were 10 CPUO and 20 healthy subjects who participated in this study. The median IL-31 level in the CPUO group was significantly higher than in the healthy group (127.3 vs 34.4 pg/mL; P < .001). The presence of CPUO was independently associated with IL-31 levels with a coefficient of 89.678 (P < .001). The serum IL-31 cutoff point for CPUO was 56.8 pg/mL, with an area under the receiver operating characteristic curve (ROC) of 100%. Chronic pruritus of unknown origin was significantly and independently associated with higher IL-31 levels. Further clinical trials of IL-31-related treatment may be justified in CPUO patients.

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Citations

Dec 12, 2020·Heliyon·Suteeraporn ChaowattanapanitMongkhon Sompornrattanaphan
Mar 2, 2021·Frontiers in Medicine·Kenji Kabashima, Hiroyuki Irie
Apr 4, 2021·Vaccines·Simone GarcovichGiampiero Girolomoni
May 1, 2021·Journal of Clinical Medicine·Masutaka Furue, Mihoko Furue
May 26, 2021·Experimental Dermatology·Giuseppe IngrasciGil Yosipovitch

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ISS
ELISA

Software Mentioned

STATA

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